Associated Papers
Calcium handling remodeling in dilated cardiomyopathy: From molecular mechanisms to targeted therapies.
Wang Y et al.
Channels (austin, Tex.), 2025
5,7-Dimethoxychroman-3-yl 4-methoxybenzoate Has a Unique Effect upon the Modulation of Mutant Cardiac Muscle Thin Filament Function and Dynamics due to Phosphorylation of Troponin I.
Yang Z et al.
Acs Pharmacology & Translational Science, 2025
Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy-associated TPM1 variants.
Halder SS et al.
The Journal of Clinical Investigation, 2024
Novel Mutation Lys30Glu in the TPM1 Gene Leads to Pediatric Left Ventricular Non-Compaction and Dilated Cardiomyopathy via Impairment of Structural and Functional Properties of Cardiac Tropomyosin.
Zaklyazminskaya EV et al.
International Journal of Molecular Sciences, 2024
Dilated Cardiomyopathy - Exploring the Underlying Causes.
Wieczorek DF
Medical Research Archives, 2024
Identification of a novel likely pathogenic TPM1 variant linked to hypertrophic cardiomyopathy in a family with sudden cardiac death.
Azimi A et al.
Esc Heart Failure, 2024
Protein phosphatase 2A anchoring disruptor gene therapy for familial dilated cardiomyopathy.
Li X et al.
Molecular Therapy. Methods & Clinical Development, 2024
Functional assays reveal the pathogenic mechanism of a de novo tropomyosin variant identified in patient with dilated cardiomyopathy.
Barrick SK et al.
Journal of Molecular and Cellular Cardiology, 2023
Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L.
Halder SS et al.
Pnas Nexus, 2023
Diagnostic yield of genetic testing in a multinational heterogeneous cohort of 2088 DCM patients.
Heliö K et al.
Frontiers in Cardiovascular Medicine, 2023
Dilated cardiomyopathy: a new insight into the rare but common cause of heart failure.
Giri P et al.
Heart Failure Reviews, 2022
Genetic predisposition study of heart failure and its association with cardiomyopathy.
Kaviarasan V et al.
The Egyptian Heart Journal : (ehj) : Official Bulletin of the Egyptian Society of Cardiology, 2022
Identification of a novel missense mutation in the TPM1 gene via exome sequencing in a Chinese family with dilated cardiomyopathy: A case report and literature review.
Man Y et al.
Medicine, 2022
Thin filament cardiomyopathies: A review of genetics, disease mechanisms, and emerging therapeutics.
Keyt LK et al.
Frontiers in Cardiovascular Medicine, 2022
Cardiomyocyte Dysfunction in Inherited Cardiomyopathies.
Hassoun R et al.
International Journal of Molecular Sciences, 2021
Upregulated Angiogenesis Is Incompetent to Rescue Dilated Cardiomyopathy Phenotype in Mice.
Arif M et al.
Cells, 2021
Tropomyosin pseudo-phosphorylation can rescue the effects of cardiomyopathy-associated mutations.
Nefedova VV et al.
International Journal of Biological Macromolecules, 2021
Thin filament dysfunctions caused by mutations in tropomyosin Tpm3.12 and Tpm1.1.
Moraczewska J
Journal of Muscle Research and Cell Motility, 2020
Cardiomyopathy-associated mutations in tropomyosin differently affect actin-myosin interaction at single-molecule and ensemble levels.
Kopylova GV et al.
Journal of Muscle Research and Cell Motility, 2019
Association of single nucleotide polymorphisms in the 3'UTR region of TPM1 gene with dilated cardiomyopathy: A case-control study.
Yao Q et al.
Medicine, 2019
Estimating dispensable content in the human interactome.
Ghadie M et al.
Nature Communications, 2019
Moving beyond simple answers to complex disorders in sarcomeric cardiomyopathies: the role of integrated systems.
Deranek AE et al.
Pflugers Archiv : European Journal of Physiology, 2019
Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy.
Rajan S et al.
The Journal of Biological Chemistry, 2019
Combinatorial interactions of genetic variants in human cardiomyopathy.
Deacon DC et al.
Nature Biomedical Engineering, 2019
Sarcomere gene variants act as a genetic trigger underlying the development of left ventricular noncompaction.
Takasaki A et al.
Pediatric Research, 2018
Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.
Bondue A et al.
Cardiovascular Research, 2018
The Molecular Mechanisms of Mutations in Actin and Myosin that Cause Inherited Myopathy.
Marston S
International Journal of Molecular Sciences, 2018
Functional role of the core gap in the middle part of tropomyosin.
Matyushenko AM et al.
The Febs Journal, 2018
Structural destabilization of tropomyosin induced by the cardiomyopathy-linked mutation R21H.
Ly T et al.
Protein Science : a Publication of the Protein Society, 2018
Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin.
Sheehan A et al.
Frontiers in Physiology, 2018