Associated Papers
Identification of a novel likely pathogenic TPM1 variant linked to hypertrophic cardiomyopathy in a family with sudden cardiac death.
Azimi A et al.
Esc Heart Failure, 2024
Novel Mutation Glu98Lys in Cardiac Tropomyosin Alters Its Structure and Impairs Myocardial Relaxation.
Matyushenko AM et al.
International Journal of Molecular Sciences, 2023
Cardiomyocyte Dysfunction in Inherited Cardiomyopathies.
Hassoun R et al.
International Journal of Molecular Sciences, 2021
Sarcomere gene variants act as a genetic trigger underlying the development of left ventricular noncompaction.
Takasaki A et al.
Pediatric Research, 2018
Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation.
Zheng W et al.
Journal of Muscle Research and Cell Motility, 2016
Why Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?
Marston SB
Frontiers in Physiology, 2016
Energy landscapes reveal the myopathic effects of tropomyosin mutations.
Orzechowski M et al.
Archives of Biochemistry and Biophysics, 2014
A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.
Bai F et al.
Journal of Muscle Research and Cell Motility, 2013
Nuclear tropomyosin and troponin in striated muscle: new roles in a new locale?
Chase PB et al.
Journal of Muscle Research and Cell Motility, 2013
Alpha-tropomyosin mutations in inherited cardiomyopathies.
Redwood C et al.
Journal of Muscle Research and Cell Motility, 2013
Integrative structural modelling of the cardiac thin filament: energetics at the interface and conservation patterns reveal a spotlight on period 2 of tropomyosin.
Margaret Sunitha S et al.
Bioinformatics and Biology Insights, 2012
Thin filament mutations: developing an integrative approach to a complex disorder.
Tardiff JC
Circulation Research, 2011
Enhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutations.
Bai F et al.
Biophysical Journal, 2011
Identification of a novel TPM1 mutation in a family with left ventricular noncompaction and sudden death.
Chang B et al.
Molecular Genetics and Metabolism, 2011
Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.
Rajan S et al.
Circulation, 2010
An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity.
Jagatheesan G et al.
American Journal of Physiology. Heart and Circulatory Physiology, 2009
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.
Jagatheesan G et al.
American Journal of Physiology. Heart and Circulatory Physiology, 2007
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.
Rajan S et al.
Circulation Research, 2007
The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments.
Mirza M et al.
The Journal of Biological Chemistry, 2007
The Delta 14 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin.
Gafurov B et al.
Biochemistry, 2004
Effects of cardiomyopathic mutations on the biochemical and biophysical properties of the human alpha-tropomyosin.
Hilario E et al.
European Journal of Biochemistry, 2004
Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractility.
Gaffin RD et al.
The Journal of Physiology, 2004
Cardiomyopathic tropomyosin mutations that increase thin filament Ca2+ sensitivity and tropomyosin N-domain flexibility.
Heller MJ et al.
The Journal of Biological Chemistry, 2003
Prevalence and spectrum of thin filament mutations in an outpatient referral population with hypertrophic cardiomyopathy.
Van Driest SL et al.
Circulation, 2003
The role of tropomyosin in the regulation of myocardial contraction and relaxation.
Wolska BM et al.
Pflugers Archiv : European Journal of Physiology, 2003
Variable clinical manifestation of a novel missense mutation in the alpha-tropomyosin (TPM1) gene in familial hypertrophic cardiomyopathy.
Jongbloed RJ et al.
Journal of the American College of Cardiology, 2003
Folding and function of the troponin tail domain. Effects of cardiomyopathic troponin T mutations.
Hinkle A et al.
The Journal of Biological Chemistry, 2003
Molecular diagnosis of myocardial disease.
Towbin JA et al.
Expert Review of Molecular Diagnostics, 2002
Molecular mechanisms of inherited cardiomyopathies.
Fatkin D et al.
Physiological Reviews, 2002
Genetic bases of hypertrophic cardiomyopathy.
Mattos BP
Arquivos Brasileiros De Cardiologia, 2002
Calcium, contractions, and tropomyosin Focus on "divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins".
Marston SB et al.
Physiological Genomics, 2002
Divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins.
Michele DE et al.
Physiological Genomics, 2002
Invited Review: pathophysiology of cardiac muscle contraction and relaxation as a result of alterations in thin filament regulation.
Hernandez OM et al.
Journal of Applied Physiology (bethesda, Md. : 1985), 2001
Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis.
Karibe A et al.
Circulation, 2001
Molecular genetics of hypertrophic cardiomyopathy.
Towbin JA
Current Cardiology Reports, 2000
The molecular genetics of hypertrophic cardiomyopathy: prognostic implications.
Sorajja P et al.
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology, 2000
Physiological consequences of tropomyosin mutations associated with cardiac and skeletal myopathies.
Michele DE et al.
Journal of Molecular Medicine (berlin, Germany), 2000
Direct, convergent hypersensitivity of calcium-activated force generation produced by hypertrophic cardiomyopathy mutant alpha-tropomyosins in adult cardiac myocytes.
Michele DE et al.
Nature Medicine, 1999
Familial hypertrophic cardiomyopathy: from mutations to functional defects.
Bonne G et al.
Circulation Research, 1998
Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene.
Yamauchi-Takihara K et al.
Heart (british Cardiac Society), 1996
[Hypertrophic cardiomyopathy. Electrocardiographic analysis of ventricular depolarization].
Mattos BP et al.
Arquivos Brasileiros De Cardiologia, 1984
[Hypertrophic cardiomyopathy].
Bersano E et al.
Arquivos Brasileiros De Cardiologia, 1982