Varaico: Literature-Extracted Genetic Variants

Gene:TPM1
Variant:p.A78V
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TPM1

NM_001018005.2:p.A78V

Associated Papers

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.

Farman GP et al.

Archives of Biochemistry and Biophysics, 2018

The shape and flexibility of tropomyosin coiled coils: implications for actin filament assembly and regulation.

Li XE et al.

Journal of Molecular Biology, 2010

Local destabilization of the tropomyosin coiled coil gives the molecular flexibility required for actin binding.

Singh A et al.

Biochemistry, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."