Associated Papers
The Twisting and Untwisting of Actin and Tropomyosin Filaments Are Involved in the Molecular Mechanisms of Muscle Contraction, and Their Disruption Can Result in Muscle Disorders.
Borovikov YS et al.
International Journal of Molecular Sciences, 2025
Identification of a novel likely pathogenic TPM1 variant linked to hypertrophic cardiomyopathy in a family with sudden cardiac death.
Azimi A et al.
Esc Heart Failure, 2024
Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7.
Borovikov YS et al.
International Journal of Molecular Sciences, 2021
Thin filament dysfunctions caused by mutations in tropomyosin Tpm3.12 and Tpm1.1.
Moraczewska J
Journal of Muscle Research and Cell Motility, 2020
The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies.
Borovikov YS et al.
International Journal of Molecular Sciences, 2018
Molecular mechanisms of dysfunction of muscle fibres associated with Glu139 deletion in TPM2 gene.
Borovikov YS et al.
Scientific Reports, 2017
Molecular mechanisms of deregulation of the thin filament associated with the R167H and K168E substitutions in tropomyosin Tpm1.1.
Borovikov YS et al.
Archives of Biochemistry and Biophysics, 2017
Abnormal movement of tropomyosin and response of myosin heads and actin during the ATPase cycle caused by the Arg167His, Arg167Gly and Lys168Glu mutations in TPM1 gene.
Borovikov YS et al.
Archives of Biochemistry and Biophysics, 2016
Impaired tropomyosin-troponin interactions reduce activation of the actin thin filament.
Robaszkiewicz K et al.
Biochimica Et Biophysica Acta, 2015
Energy landscapes reveal the myopathic effects of tropomyosin mutations.
Orzechowski M et al.
Archives of Biochemistry and Biophysics, 2014
Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients.
Marston S et al.
Human Molecular Genetics, 2013
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