Associated Papers
Ancestral Diversity in Pharmacogenomics Affects Treatment for Hispanic/Latine Populations With Inflammatory Bowel Disease.
Ioannou S et al.
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 2025
Genotype and Phenotype Correlation of the TPMT∗8 Allele in Thiopurine Metabolism.
Sterner RM et al.
The Journal of Molecular Diagnostics : Jmd, 2024
APF2: an improved ensemble method for pharmacogenomic variant effect prediction.
Zhou Y et al.
The Pharmacogenomics Journal, 2024
Population-Specific Distribution of TPMT Deficiency Variants and Ancestry Proportions in Ecuadorian Ethnic Groups: Towards Personalized Medicine.
Gallardo-Cóndor J et al.
Therapeutics and Clinical Risk Management, 2023
Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia.
Yang W et al.
Jama Network Open, 2022
Role of Genetic Polymorphisms in Drug-Metabolizing Enzyme-Mediated Toxicity and Pharmacokinetic Resistance to Anti-Cancer Agents: A Review on the Pharmacogenomics Aspect.
Narendra G et al.
Clinical Pharmacokinetics, 2022
Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data.
Lanillos J et al.
Npj Genomic Medicine, 2022
Impact of Variants in the ATIC and ARID5B Genes on Therapeutic Failure with Imatinib in Patients with Chronic Myeloid Leukemia.
Cereja Pantoja KBC et al.
Genes, 2022
Comprehensive characterization of pharmacogenetic variants in TPMT and NUDT15 in children with acute lymphoblastic leukemia.
Moriyama T et al.
Pharmacogenetics and Genomics, 2022
Identification of pharmacogenetic variants from large scale next generation sequencing data in the Saudi population.
Goljan E et al.
Plos One, 2022
Understanding thiopurine methyltransferase polymorphisms for the targeted treatment of hematologic malignancies.
Franca R et al.
Expert Opinion on Drug Metabolism & Toxicology, 2021
Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.
Kim B et al.
Translational and Clinical Pharmacology, 2021
Population-scale predictions of DPD and TPMT phenotypes using a quantitative pharmacogene-specific ensemble classifier.
Zhou Y et al.
British Journal of Cancer, 2020
Identification of rare defective allelic variants in cases of thiopurine S-methyltransferase deficient activity.
Chansavang A et al.
Pharmacogenomics, 2020
Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT.
Harmand PO et al.
Genes, 2020
Association between the TPMT*3C (rs1142345) Polymorphism and the Risk of Death in the Treatment of Acute Lymphoblastic Leukemia in Children from the Brazilian Amazon Region.
Cardoso de Carvalho D et al.
Genes, 2020
Applying Multiplex Assays to Understand Variation in Pharmacogenes.
Chiasson M et al.
Clinical Pharmacology and Therapeutics, 2019
An optimized prediction framework to assess the functional impact of pharmacogenetic variants.
Zhou Y et al.
The Pharmacogenomics Journal, 2019
Multiplex assessment of protein variant abundance by massively parallel sequencing.
Matreyek KA et al.
Nature Genetics, 2018
In Vitro Protein Stability of Two Naturally Occurring Thiopurine S-Methyltransferase Variants: Biophysical Characterization of TPMT*6 and TPMT*8.
Wennerstrand P et al.
Acs Omega, 2017
Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.
Liu C et al.
Clinical Pharmacology and Therapeutics, 2017
Structural and functional impact of missense mutations in TPMT: An integrated computational approach.
Fazel-Najafabadi E et al.
Computational Biology and Chemistry, 2015
Germline oncopharmacogenetics, a promising field in cancer therapy.
Pesenti C et al.
Cellular Oncology (dordrecht, Netherlands), 2015
Preparing Triple-Compound Heterozygous Control Material for Molecular Diagnostics of TPMT Allelic Variants.
Beránek M et al.
Folia Biologica, 2015
Identification of a novel thiopurine S-methyltransferase allele (TPMT*37).
Roberts RL et al.
Pharmacogenetics and Genomics, 2014
Single nucleotide polymorphism and its dynamics for pharmacogenomics.
Katara P
Interdisciplinary Sciences, Computational Life Sciences, 2014
Distribution of genetic polymorphisms of genes encoding drug metabolizing enzymes & drug transporters - a review with Indian perspective.
Umamaheswaran G et al.
The Indian Journal of Medical Research, 2014
Nomenclature for alleles of the thiopurine methyltransferase gene.
Appell ML et al.
Pharmacogenetics and Genomics, 2013
Thiopurine S-methyltransferase alleles, TPMT(*)2, (*)3B and (*)3C, and genotype frequencies in an Indian population.
Murugesan R et al.
Experimental and Therapeutic Medicine, 2010
Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.
Takatsu N et al.
Journal of Gastroenterology and Hepatology, 2009
TPMT genetic variations in populations of the Russian Federation.
Samochatova EV et al.
Pediatric Blood & Cancer, 2009
Highly multiplexed genotyping of thiopurine s-methyltransferase variants using MALD-TOF mass spectrometry: reliable genotyping in different ethnic groups.
Schaeffeler E et al.
Clinical Chemistry, 2008
Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2 - *24).
Ujiie S et al.
Pharmacogenetics and Genomics, 2008
Clinical pharmacology and pharmacogenetics of thiopurines.
Sahasranaman S et al.
European Journal of Clinical Pharmacology, 2008
Four human thiopurine s-methyltransferase alleles severely affect protein structure and dynamics.
Rutherford K et al.
Journal of Molecular Biology, 2008
Genotyping panel for assessing response to cancer chemotherapy.
Dai Z et al.
Bmc Medical Genomics, 2008
Do the distribution patterns of polymorphisms at the thiopurine S-methyltransferase locus in sub-Saharan populations need revision? Hints from Cabinda and Mozambique.
Oliveira E et al.
European Journal of Clinical Pharmacology, 2007
Rapid genotyping of common deficient thiopurine S-methyltransferase alleles using the DNA-microchip technique.
Nasedkina TV et al.
European Journal of Human Genetics : Ejhg, 2006
Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics.
Salavaggione OE et al.
Pharmacogenetics and Genomics, 2005
Predicting drug response and toxicity based on gene polymorphisms.
Robert J et al.
Critical Reviews in Oncology/hematology, 2005
Genotyping of thiopurine methyltransferase using pyrosequencing.
Okada Y et al.
Biological & Pharmaceutical Bulletin, 2005
Comprehensive screening of the thiopurine methyltransferase polymorphisms by denaturing high-performance liquid chromatography.
Udaka T et al.
Genetic Testing, 2005
Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.
Lindqvist M et al.
Pharmacogenetics, 2004
Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.
Haglund S et al.
Clinical Chemistry, 2004
Clinical utility of thiopurine S-methyltransferase genotyping.
Corominas H et al.
American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice, 2004
[Relationship between single nucleotide polymorphisms in thiopurine methyltransferase gene and tolerance to thiopurines in acute leukemia].
Ma XL et al.
Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics, 2003
Genetic polymorphism of thiopurine S-methyltransferase in Argentina.
Laróvere LE et al.
Annals of Clinical Biochemistry, 2003
Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations.
Chang JG et al.
Pharmacogenetics, 2002