Associated Papers
Population frequencies of thiopurine-related pharmacogenes in healthy individuals from Kosovo.
Pasha F et al.
Human Genome Variation, 2026
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update.
Maillard M et al.
Clinical Pharmacology and Therapeutics, 2026
Inferring germline pharmacogenomics from tumor transcriptome.
Yang W et al.
Pharmacogenetics and Genomics, 2026
Decoding genetic divergence: TPMT and NUDT15 polymorphisms in north India mirror Caucasian ancestry.
Singh A et al.
Intestinal Research, 2026
Clinical Implementation of Pharmacogenomics and Drug-Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow-Up.
Tremmel R et al.
Clinical Pharmacology and Therapeutics, 2026
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between TPMT/NUDT15 and thiopurines.
Coenen MJH et al.
European Journal of Human Genetics : Ejhg, 2026
Pharmacogenetic Analysis of TPMT and NUDT15 in a European Pediatric Cohort with IBD and Autoimmune Diseases: Frequency Data and Clinical Relevance.
Pau A et al.
Genes, 2025
Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia.
Newman H et al.
Hemasphere, 2025
TPMT Genotyping in 1000 Indian Patients: 14-Year Experience from a Tertiary-Care Hospital.
Paradkar MU et al.
Ejifcc, 2025
Thiopurine S-methyltransferase (TPMT) activity cutoffs in the Thai population.
Jinda P et al.
Annals of Clinical Biochemistry, 2025
Assessment of thiopurine S-methyltransferase allele frequencies and phenotype-genotype concordance in a Tunisian population.
Souissi S et al.
Drug Metabolism and Personalized Therapy, 2025
Examination of the TPMT and NUDT15*3 Variants to Predict the Response to Thiopurines in an Italian Cohort of Patients with Inflammatory Bowel Disease.
Tavano F et al.
International Journal of Molecular Sciences, 2025
Are single nucleotide polymorphisms underutilized for guiding treatment of inflammatory bowel disease?
van der Werf J et al.
Immunology and Cell Biology, 2025
Clinical relevance of thiopurine methyltransferase genotype testing for azathioprine in dermatology.
Ramassamy S et al.
Clinical and Experimental Dermatology, 2025
Pharmacogenomic variants in the Pumi population from Yunnan, China.
Yang X et al.
Gene, 2025
Clinical Pharmacogenetics: Results After Implementation of Preemptive Tests in Daily Routine.
Díaz-Villamarín X et al.
Journal of Personalized Medicine, 2025
Real-time genomic characterization of pediatric acute leukemia using adaptive sampling.
Geyer J et al.
Leukemia, 2025
Persistent postremission clonal hematopoiesis shapes the relapse trajectories of acute myeloid leukemia.
Chow RD et al.
Blood Advances, 2025
The evaluation of the impact of NUDT15 variants on thiopurine metabolism in Japanese children with acute lymphoblastic leukemia.
Tanaka Y et al.
Cancer Chemotherapy and Pharmacology, 2025
Relationship Between Thiopurine S-Methyltransferase Genotype and Phenotype in Pediatric Acute Lymphoblastic Leukemia in Addis Ababa, Ethiopia.
Ali AM et al.
The Journal of Pediatric Pharmacology and Therapeutics : Jppt : the Official Journal of Ppag, 2025
Effectiveness and safety of thiopurines in inflammatory bowel disease patients with NUDT15 polymorphism: a real-world retrospective study.
Chatterjee A et al.
Expert Review of Clinical Pharmacology, 2025
Thiopurine S-methyltransferase - An important intersection of drug-drug interactions in thiopurine treatment.
Urbančič D et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2025
Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical Practice.
Leong IUS et al.
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 2025
Real-time genomic characterization of pediatric acute leukemia using adaptive sampling.
Geyer J et al.
Biorxiv : the Preprint Server for Biology, 2025
Value of Pharmacogenetic Testing Assessed with Real-World Drug Utilization and Genotype Data.
Litonius K et al.
Clinical Pharmacology and Therapeutics, 2025
Gene polymorphisms associated with immunosuppressant adverse effects in systemic lupus erythematosus: a narrative review.
Hamdani S et al.
Frontiers in Genetics, 2025
Higher prevalence of NUDT15 rs116855232 compared to TPMT rs1142345 in a Chinese cohort and its implications for thiopurine therapy.
Zhao C et al.
Frontiers in Pharmacology, 2025
Exploring a novel model for newborn genetic screening in Ningxia, northern China: A retrospective observational study.
Mao X et al.
Medicine, 2024
Clinical Benefits and Utility of Pretherapeutic DPYD and UGT1A1 Testing in Gastrointestinal Cancer: A Secondary Analysis of the PREPARE Randomized Clinical Trial.
Roncato R et al.
Jama Network Open, 2024
Phenotype driven molecular genetic test recommendation for diagnosing pediatric rare disorders.
Chen F et al.
Npj Digital Medicine, 2024
Early drivers of clonal hematopoiesis shape the evolutionary trajectories of de novo acute myeloid leukemia.
Chow RD et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
Predictive role of ITPA genetic variants in thiopurine-related myelotoxicity in Crohn's disease patients.
Salazar J et al.
The Pharmacogenomics Journal, 2024
APF2: an improved ensemble method for pharmacogenomic variant effect prediction.
Zhou Y et al.
The Pharmacogenomics Journal, 2024
Association of TPMT and NUDT15 gene polymorphisms with azathioprine-induced leukopenia: A case-control study in Eastern India.
Mitra S et al.
Indian Journal of Pharmacology, 2024
A New Cloud-Native Tool for Pharmacogenetic Analysis.
Yuan DY et al.
Genes, 2024
Transcriptome analysis reveals involvement of thiopurine S-methyltransferase in oxidation-reduction processes.
Šmid A et al.
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 2024
NUDT15 and TPMT polymorphisms in three distinct native populations of the Brazilian Amazon.
Perini JA et al.
Frontiers in Pharmacology, 2024
Beyond Single Diagnosis: Exploring Multidiagnostic Realities in Pediatric Patients through Genome Sequencing.
Guo F et al.
Human Mutation, 2024
Impact of Mercaptopurine Metabolites on Disease Outcome in the AIEOP-BFM ALL 2009 Protocol for Acute Lymphoblastic Leukemia.
Franca R et al.
Clinical Pharmacology and Therapeutics, 2023
Frequencies of pharmacogenomic alleles across biogeographic groups in a large-scale biobank.
Li B et al.
American Journal of Human Genetics, 2023
Thiopurine Methyltransferase Intermediate Metabolizer Status and Thiopurine-Associated Toxicity During Maintenance Therapy in Childhood Acute Lymphoblastic Leukemia.
Schwarz UI et al.
Clinical Pharmacology and Therapeutics, 2023
TPMT gene polymorphisms (c.238G>C, c.460G>A and c.719A>G) in a healthy Venezuelan population.
Mora Y et al.
Pharmacogenomics, 2023
Pharmacogenetics of anxiety and depression in Alzheimer's disease.
Cacabelos R et al.
Pharmacogenomics, 2023