Associated Papers
Pharmacogenomic Assessment of Genes Implicated in Thiopurine Metabolism and Toxicity in a UK Cohort of Pediatric Patients With Inflammatory Bowel Disease.
Coelho T et al.
Inflammatory Bowel Diseases, 2025
Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.
Kim B et al.
Translational and Clinical Pharmacology, 2021
Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT.
Harmand PO et al.
Genes, 2020
Added Value of Clinical Sequencing: WGS-Based Profiling of Pharmacogenes.
Caspar SM et al.
International Journal of Molecular Sciences, 2020
Use of Whole Genome Sequencing for Diagnosis and Discovery in the Cancer Genetics Clinic.
Foley SB et al.
Ebiomedicine, 2015
Preparing Triple-Compound Heterozygous Control Material for Molecular Diagnostics of TPMT Allelic Variants.
Beránek M et al.
Folia Biologica, 2015
Identification of a novel thiopurine S-methyltransferase allele (TPMT*37).
Roberts RL et al.
Pharmacogenetics and Genomics, 2014
Nomenclature for alleles of the thiopurine methyltransferase gene.
Appell ML et al.
Pharmacogenetics and Genomics, 2013
A new thiopurine s-methyltransferase haplotype associated with intolerance to azathioprine.
Colleoni L et al.
Journal of Clinical Pharmacology, 2013
TPMT genetic variations in populations of the Russian Federation.
Samochatova EV et al.
Pediatric Blood & Cancer, 2009
Highly multiplexed genotyping of thiopurine s-methyltransferase variants using MALD-TOF mass spectrometry: reliable genotyping in different ethnic groups.
Schaeffeler E et al.
Clinical Chemistry, 2008
Clinical pharmacology and pharmacogenetics of thiopurines.
Sahasranaman S et al.
European Journal of Clinical Pharmacology, 2008
Genotyping panel for assessing response to cancer chemotherapy.
Dai Z et al.
Bmc Medical Genomics, 2008
Genetic analyses of thiopurine methyltransferase polymorphisms in Greenlandic and Danish populations.
Toft N et al.
Acta Paediatrica (oslo, Norway : 1992), 2006
Rapid genotyping of common deficient thiopurine S-methyltransferase alleles using the DNA-microchip technique.
Nasedkina TV et al.
European Journal of Human Genetics : Ejhg, 2006
Genetic testing for pharmacogenetics and its clinical application in drug therapy.
Hiratsuka M et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 2006
Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics.
Salavaggione OE et al.
Pharmacogenetics and Genomics, 2005
Predicting drug response and toxicity based on gene polymorphisms.
Robert J et al.
Critical Reviews in Oncology/hematology, 2005
Genotyping of thiopurine methyltransferase using pyrosequencing.
Okada Y et al.
Biological & Pharmaceutical Bulletin, 2005
Arrayed primer extension: a robust and reliable genotyping platform for the diagnosis of single gene disorders: beta-thalassemia and thiopurine methyltransferase deficiency.
Lu Y et al.
Genetic Testing, 2005
Pharmacogenetics of inflammatory bowel disease.
Mascheretti S et al.
Best Practice & Research. Clinical Gastroenterology, 2004
Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.
Lindqvist M et al.
Pharmacogenetics, 2004
A multiplexed allele-specific polymerase chain reaction assay for the detection of common thiopurine S-methyltransferase (TPMT) mutations.
Roberts RL et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 2004
Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.
Haglund S et al.
Clinical Chemistry, 2004
Clinical utility of thiopurine S-methyltransferase genotyping.
Corominas H et al.
American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice, 2004
[Relationship between single nucleotide polymorphisms in thiopurine methyltransferase gene and tolerance to thiopurines in acute leukemia].
Ma XL et al.
Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics, 2003
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.
Watanabe I et al.
Clinical Pharmacology and Therapeutics, 2003
Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations.
Chang JG et al.
Pharmacogenetics, 2002
Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukaemia.
Ando M et al.
Pharmacogenetics, 2001
High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC.
Schaeffeler E et al.
Clinical Chemistry, 2001
Recent advances in the pharmacogenomics of thiopurine methyltransferase.
Coulthard SA et al.
The Pharmacogenomics Journal, 2001
Genotyping of eight thiopurine methyltransferase mutations: three-color multiplexing, "two-color/shared" anchor, and fluorescence-quenching hybridization probe assays based on thermodynamic nearest-neighbor probe design.
Schütz E et al.
Clinical Chemistry, 2000
Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance.
Krynetski EY et al.
Pharmacology, 2000
Screening of thiopurine S-methyltransferase mutations by horizontal conformation-sensitive gel electrophoresis.
Alves S et al.
Human Mutation, 2000
Inherited variations in drug-metabolizing enzymes: significance in clinical oncology.
Iyer L
Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology, 1999
Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm.
Krynetski EY et al.
Pharmaceutical Research, 1999
Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis.
Spire-Vayron de la Moureyre C et al.
Human Mutation, 1998
Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms.
Otterness D et al.
Clinical Pharmacology and Therapeutics, 1997
Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms.
Li J et al.
Mutation Research. Reviews in Mutation Research, 0