Associated Papers
APF2: an improved ensemble method for pharmacogenomic variant effect prediction.
Zhou Y et al.
The Pharmacogenomics Journal, 2024
A bioinformatics approach to the identification of novel deleterious mutations of human TPMT through validated screening and molecular dynamics.
Saxena S et al.
Scientific Reports, 2022
Role of Genetic Polymorphisms in Drug-Metabolizing Enzyme-Mediated Toxicity and Pharmacokinetic Resistance to Anti-Cancer Agents: A Review on the Pharmacogenomics Aspect.
Narendra G et al.
Clinical Pharmacokinetics, 2022
Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data.
Lanillos J et al.
Npj Genomic Medicine, 2022
Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis.
Jena A et al.
Expert Review of Clinical Pharmacology, 2021
An optimized prediction framework to assess the functional impact of pharmacogenetic variants.
Zhou Y et al.
The Pharmacogenomics Journal, 2019
Multiplex assessment of protein variant abundance by massively parallel sequencing.
Matreyek KA et al.
Nature Genetics, 2018
Structural and functional impact of missense mutations in TPMT: An integrated computational approach.
Fazel-Najafabadi E et al.
Computational Biology and Chemistry, 2015
Nomenclature for alleles of the thiopurine methyltransferase gene.
Appell ML et al.
Pharmacogenetics and Genomics, 2013
Phenotype prediction of nonsynonymous single nucleotide polymorphisms in human phase II drug/xenobiotic metabolizing enzymes: perspectives on molecular evolution.
Hao D et al.
Science China. Life Sciences, 2010
Thiopurine S-methyltransferase alleles, TPMT(*)2, (*)3B and (*)3C, and genotype frequencies in an Indian population.
Murugesan R et al.
Experimental and Therapeutic Medicine, 2010
Highly multiplexed genotyping of thiopurine s-methyltransferase variants using MALD-TOF mass spectrometry: reliable genotyping in different ethnic groups.
Schaeffeler E et al.
Clinical Chemistry, 2008
Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2 - *24).
Ujiie S et al.
Pharmacogenetics and Genomics, 2008
Clinical pharmacology and pharmacogenetics of thiopurines.
Sahasranaman S et al.
European Journal of Clinical Pharmacology, 2008
Genetic testing for pharmacogenetics and its clinical application in drug therapy.
Hiratsuka M et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 2006
Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics.
Salavaggione OE et al.
Pharmacogenetics and Genomics, 2005
Predicting drug response and toxicity based on gene polymorphisms.
Robert J et al.
Critical Reviews in Oncology/hematology, 2005
Genotyping of thiopurine methyltransferase using pyrosequencing.
Okada Y et al.
Biological & Pharmaceutical Bulletin, 2005
Pharmacogenetics of inflammatory bowel disease.
Mascheretti S et al.
Best Practice & Research. Clinical Gastroenterology, 2004
Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.
Lindqvist M et al.
Pharmacogenetics, 2004
Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.
Haglund S et al.
Clinical Chemistry, 2004
Clinical utility of thiopurine S-methyltransferase genotyping.
Corominas H et al.
American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice, 2004
[Relationship between single nucleotide polymorphisms in thiopurine methyltransferase gene and tolerance to thiopurines in acute leukemia].
Ma XL et al.
Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics, 2003
Genetic polymorphism of thiopurine S-methyltransferase in Argentina.
Laróvere LE et al.
Annals of Clinical Biochemistry, 2003
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.
Watanabe I et al.
Clinical Pharmacology and Therapeutics, 2003
Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations.
Chang JG et al.
Pharmacogenetics, 2002
Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukaemia.
Ando M et al.
Pharmacogenetics, 2001
High-throughput genotyping of thiopurine S-methyltransferase by denaturing HPLC.
Schaeffeler E et al.
Clinical Chemistry, 2001
Recent advances in the pharmacogenomics of thiopurine methyltransferase.
Coulthard SA et al.
The Pharmacogenomics Journal, 2001
Genotyping of eight thiopurine methyltransferase mutations: three-color multiplexing, "two-color/shared" anchor, and fluorescence-quenching hybridization probe assays based on thermodynamic nearest-neighbor probe design.
Schütz E et al.
Clinical Chemistry, 2000
Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance.
Krynetski EY et al.
Pharmacology, 2000
Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia.
McLeod HL et al.
Leukemia, 2000
Screening of thiopurine S-methyltransferase mutations by horizontal conformation-sensitive gel electrophoresis.
Alves S et al.
Human Mutation, 2000
Inherited variations in drug-metabolizing enzymes: significance in clinical oncology.
Iyer L
Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology, 1999
Pharmacogenetics in the practice of laboratory medicine.
Linder MW et al.
Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology, 1999
Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis.
Spire-Vayron de la Moureyre C et al.
Human Mutation, 1998
Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms.
Otterness D et al.
Clinical Pharmacology and Therapeutics, 1997
Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms.
Li J et al.
Mutation Research. Reviews in Mutation Research, 0