Associated Papers
A ligand-mimetic anti-TREM2 agonist antibody elevates soluble TREM2 and ameliorates pathology in mouse models of Alzheimer's disease and multiple sclerosis.
Chen B et al.
Journal of Neuroinflammation, 2026
TREM2 Drives Neutrophil Extracellular Traps-Induced Dendritic Cell Maturation and Contributes to Lupus Progression.
Shu J et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2026
The TREM2 T96K paradox: Stronger signaling in vitro, weaker microglia in vivo.
Penati S et al.
Neuron, 2026
Alterations in the brain lipidome of Alzheimer's disease donors with rare TREM2 risk variants.
Proitsi P et al.
Brain Communications, 2026
As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition.
Cho S et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2025
The TREM2 H157Y variant is associated with more severe neurodegeneration in Alzheimer's disease and altered immune-related processes.
Tsui JSM et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025
As48, a First-in-Class Dual-Function TREM2 Modulator: Receptor Activation and Shedding Inhibition.
Cho S et al.
Biorxiv : the Preprint Server for Biology, 2025
Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.
Khani M et al.
Nature Communications, 2025
Recent Advances and Future Directions in Alzheimer's Disease Genetic Research.
Stancheva M et al.
International Journal of Molecular Sciences, 2025
Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers.
Cumplido-Mayoral I et al.
Molecular Psychiatry, 2025
TREM2 in Neurodegenerative Disorders: Mutation Spectrum, Pathophysiology, and Therapeutic Targeting.
Yang H et al.
International Journal of Molecular Sciences, 2025
Glial Cells in Alzheimer's Disease: Pathogenic Mechanisms and Therapeutic Frontiers.
Sil M et al.
Journal of Molecular Neuroscience : Mn, 2025
Genetic profiling of synchronous pituitary corticotroph adenomas.
Zhang D et al.
Pituitary, 2025
Biophysical characterization of TREM2 missense variants implicated in neurodegenerative disease.
Pillai J et al.
Computational and Structural Biotechnology Journal, 2025
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations.
Villegas-Llerena C et al.
Frontiers in Neuroscience, 2025
Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.
Khani M et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
AlzDiscovery: A computational tool to identify Alzheimer's disease-causing missense mutations using protein structure information.
Pan Q et al.
Protein Science : a Publication of the Protein Society, 2024
A Risk Variant rs6922617 in TREM Is Discrepantly Associated With Defining Neuropathological Hallmarks in the Alzheimer's Continuum.
Qian S et al.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2024
TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing.
Kiianitsa K et al.
Brain : a Journal of Neurology, 2024
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology.
Winfree RL et al.
Molecular Neurodegeneration, 2024
Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias.
Yin T et al.
Embo Reports, 2024
iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss.
Penney J et al.
Glia, 2024
Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease.
Wang L et al.
Molecular Neurodegeneration, 2024
Behavioral variant of frontotemporal dementia in carriers of biallelic TREM2 variants: cases study.
Barczak A et al.
Folia Neuropathologica, 2024
Ancestral origins of TYR and OCA2 gene mutations in oculocutaneous albinism from two admixed populations in Colombia.
Cárdenas WA et al.
Plos One, 2024
Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia.
Kwak C et al.
Biorxiv : the Preprint Server for Biology, 2023
Computational saturation mutagenesis to explore the effect of pathogenic mutations on extra-cellular domains of TREM2 associated with Alzheimer's and Nasu-Hakola disease.
Swain PS et al.
Journal of Molecular Modeling, 2023
The VCAM1-ApoE pathway directs microglial chemotaxis and alleviates Alzheimer's disease pathology.
Lau SF et al.
Nature Aging, 2023
Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2.
Ogonowski N et al.
Journal of Medical Genetics, 2023
BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias.
Yin T et al.
Biorxiv : the Preprint Server for Biology, 2023
Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.
Novotny BC et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2023
Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers.
Brase L et al.
Nature Communications, 2023
The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release.
Fu XX et al.
Brain Sciences, 2023
Insights from new in vivo models of TREM2 variants.
Jain N et al.
Molecular Neurodegeneration, 2023
Genetics of Alzheimer's disease: an East Asian perspective.
Miyashita A et al.
Journal of Human Genetics, 2023
Profiling TREM2 expression in amyotrophic lateral sclerosis.
Jericó I et al.
Brain, Behavior, and Immunity, 2023
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology.
Qiao W et al.
Molecular Neurodegeneration, 2023
Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease.
Basha SC et al.
Journal of Alzheimer's Disease : Jad, 2023
Co-occurring pathogenic variants in 6q27 associated with dementia spectrum disorders in a Peruvian family.
Alvarez KLF et al.
Frontiers in Molecular Neuroscience, 2023