Associated Papers
Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.
Khani M et al.
Nature Communications, 2025
Biophysical characterization of TREM2 missense variants implicated in neurodegenerative disease.
Pillai J et al.
Computational and Structural Biotechnology Journal, 2025
Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.
Khani M et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing.
Kiianitsa K et al.
Brain : a Journal of Neurology, 2024
Evolutionary history of adenomas to colorectal cancer in FAP families.
Yang C et al.
Frontiers in Genetics, 2024
Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.
Novotny BC et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2023
Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers.
Brase L et al.
Nature Communications, 2023
Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors.
Van Acker ZP et al.
Molecular Neurodegeneration, 2019
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers.
Del-Aguila JL et al.
Molecular Neurodegeneration, 2019
Genetic Analysis of TREM2 Variants in Tunisian Patients with Alzheimer's Disease.
Landoulsi Z et al.
Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 2018
A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature.
Dardiotis E et al.
Neurobiology of Aging, 2017
Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.
Song W et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2017
Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease.
Bonham LW et al.
Neurocase, 2017
Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression.
Sirkis DW et al.
Acta Neuropathologica Communications, 2016
Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status.
Piccio L et al.
Acta Neuropathologica, 2016
Coding variants in TREM2 increase risk for Alzheimer's disease.
Jin SC et al.
Human Molecular Genetics, 2014
The p.R47H Variant of TREM2 Gene is Associated With Late-onset Alzheimer Disease in Colombian Population.
Arboleda-Bustos CE et al.
Alzheimer Disease and Associated Disorders, 0