Associated Papers
Biophysical characterization of TREM2 missense variants implicated in neurodegenerative disease.
Pillai J et al.
Computational and Structural Biotechnology Journal, 2025
TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing.
Kiianitsa K et al.
Brain : a Journal of Neurology, 2024
Homozygous TREM2 c.549del; p.(Leu184Serfs*5) variant causing Nasu-Hakola disease in three siblings in a consanguineous Iraqi family: Case report and review of literature.
Gilani N et al.
Molecular Genetics & Genomic Medicine, 2024
Computational saturation mutagenesis to explore the effect of pathogenic mutations on extra-cellular domains of TREM2 associated with Alzheimer's and Nasu-Hakola disease.
Swain PS et al.
Journal of Molecular Modeling, 2023
Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation.
Filipello F et al.
Acta Neuropathologica, 2023
Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease.
Basha SC et al.
Journal of Alzheimer's Disease : Jad, 2023
Soluble TREM2: Innocent bystander or active player in neurological diseases?
Filipello F et al.
Neurobiology of Disease, 2022
Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries.
Duran-Aniotz C et al.
Frontiers in Neurology, 2021
Genome scale analysis of pathogenic variants targetable for single base editing.
Lavrov AV et al.
Bmc Medical Genomics, 2020
Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.
Korvatska O et al.
Frontiers in Immunology, 2020
The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives.
Wolfe CM et al.
International Journal of Molecular Sciences, 2018
Frontotemporal Dementia and Chorea Associated with a Compound Heterozygous TREM2 Mutation.
Redaelli V et al.
Journal of Alzheimer's Disease : Jad, 2018
Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.
Sirkis DW et al.
Molecular Biology of the Cell, 2017
A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature.
Dardiotis E et al.
Neurobiology of Aging, 2017
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
Kober DL et al.
Elife, 2016
Targeted sequencing approach to identify genetic mutations in Nasu-Hakola disease.
Satoh JI et al.
Intractable & Rare Diseases Research, 2016
Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set.
Ghani M et al.
Neurobiology of Aging, 2016
The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases.
Walter J
The Journal of Biological Chemistry, 2016
Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement.
Guerreiro RJ et al.
Jama Neurology, 2013
Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family.
Numasawa Y et al.
European Journal of Neurology, 2011
Absence of TREM2 polymorphisms in patients with Alzheimer's disease and Frontotemporal Lobar Degeneration.
Fenoglio C et al.
Neuroscience Letters, 2007
Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.
Paloneva J et al.
American Journal of Human Genetics, 2002
The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective.
Xing J et al.
Research and Reports in Biochemistry, 0