Varaico: Literature-Extracted Genetic Variants

Gene:TREM2
Variant:p.R98Q
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TREM2

NM_018965.4:p.R98Q

Associated Papers

Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function.

Dash R et al.

Scientific Reports, 2022

35672339 (PubMed )
Supplement: 41598_2022_13120_MOESM6_ESM.doc

Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders.

Khatri DK et al.

Current Research in Pharmacology and Drug Discovery, 2021

Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants.

Dash R et al.

Scientific Reports, 2020

32107424 (PubMed )
Supplement: 41598_2020_60561_MOESM1_ESM.docx

TREM2 is associated with increased risk for Alzheimer's disease in African Americans.

Jin SC et al.

Molecular Neurodegeneration, 2015

25886450 (PubMed )
Supplement: 13024_2015_16_MOESM6_ESM.xlsx › Table_S13

R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.

Slattery CF et al.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."