Associated Papers
Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.
Khani M et al.
Nature Communications, 2025
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.
Greven JA et al.
Molecular Neurodegeneration, 2025
Biophysical characterization of TREM2 missense variants implicated in neurodegenerative disease.
Pillai J et al.
Computational and Structural Biotechnology Journal, 2025
Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.
Khani M et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.
Greven JA et al.
Research Square, 2024
Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants.
Dean HB et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024
Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease.
Wang L et al.
Molecular Neurodegeneration, 2024
Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function.
Dash R et al.
Scientific Reports, 2022
TREM2 coding variants in Slovak Alzheimer's disease patients.
Durmanova V et al.
Journal of Integrative Neuroscience, 2022
Soluble TREM2: Innocent bystander or active player in neurological diseases?
Filipello F et al.
Neurobiology of Disease, 2022
Role of TREM2 in Alzheimer's Disease: A Long Road Ahead.
Kulkarni B et al.
Molecular Neurobiology, 2021
Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants.
Dash R et al.
Scientific Reports, 2020
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk.
Deming Y et al.
Science Translational Medicine, 2019
Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains.
Keogh MJ et al.
Journal of Neurology, Neurosurgery, and Psychiatry, 2018
Genetic Analysis of TREM2 Variants in Tunisian Patients with Alzheimer's Disease.
Landoulsi Z et al.
Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 2018
Common and Rare Genetic Risk Factors Converge in Protein Interaction Networks Underlying Schizophrenia.
Chang X et al.
Frontiers in Genetics, 2018
A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature.
Dardiotis E et al.
Neurobiology of Aging, 2017
Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource.
Keogh MJ et al.
Genome Research, 2017
TREM2 is associated with increased risk for Alzheimer's disease in African Americans.
Jin SC et al.
Molecular Neurodegeneration, 2015
R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.
Slattery CF et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2014
Heterozygous TREM2 mutations in frontotemporal dementia.
Borroni B et al.
Neurobiology of Aging, 2014
Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population.
Miyashita A et al.
Journal of Alzheimer's Disease : Jad, 2014
TREM2 variants in Alzheimer's disease.
Guerreiro R et al.
The New England Journal of Medicine, 2013
De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia.
Xu B et al.
Nature Genetics, 2012
The p.R47H Variant of TREM2 Gene is Associated With Late-onset Alzheimer Disease in Colombian Population.
Arboleda-Bustos CE et al.
Alzheimer Disease and Associated Disorders, 0