Associated Papers
Alterations in the brain lipidome of Alzheimer's disease donors with rare TREM2 risk variants.
Proitsi P et al.
Brain Communications, 2026
The TREM2 H157Y variant is associated with more severe neurodegeneration in Alzheimer's disease and altered immune-related processes.
Tsui JSM et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025
Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.
Khani M et al.
Nature Communications, 2025
Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers.
Cumplido-Mayoral I et al.
Molecular Psychiatry, 2025
Glial Cells in Alzheimer's Disease: Pathogenic Mechanisms and Therapeutic Frontiers.
Sil M et al.
Journal of Molecular Neuroscience : Mn, 2025
Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions.
Giorgio J et al.
Nature Communications, 2025
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia.
Llibre-Guerra JJ et al.
Nature Medicine, 2025
TREM2 risk variants and associated endophenotypes in alzheimer's disease.
Dijkstra JIR et al.
Alzheimer's Research & Therapy, 2025
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.
Greven JA et al.
Molecular Neurodegeneration, 2025
Predicting the impact of missense mutations on an unresolved protein's stability, structure, and function: A case study of Alzheimer's disease-associated TREM2 R47H variant.
Pillai J et al.
Computational and Structural Biotechnology Journal, 2025
Biophysical characterization of TREM2 missense variants implicated in neurodegenerative disease.
Pillai J et al.
Computational and Structural Biotechnology Journal, 2025
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations.
Villegas-Llerena C et al.
Frontiers in Neuroscience, 2025
Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.
Khani M et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.
Greven JA et al.
Research Square, 2024
Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants.
Dean HB et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024
Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions.
Giorgio J et al.
Research Square, 2024
Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology.
Winfree RL et al.
Molecular Neurodegeneration, 2024
Innate immune activation in neurodegenerative diseases.
Castro-Gomez S et al.
Immunity, 2024
Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease.
Wang L et al.
Molecular Neurodegeneration, 2024
Behavioral variant of frontotemporal dementia in carriers of biallelic TREM2 variants: cases study.
Barczak A et al.
Folia Neuropathologica, 2024
Computational saturation mutagenesis to explore the effect of pathogenic mutations on extra-cellular domains of TREM2 associated with Alzheimer's and Nasu-Hakola disease.
Swain PS et al.
Journal of Molecular Modeling, 2023
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.
Zhong L et al.
Immunity, 2023
Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains.
Novotny BC et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2023
TREM2 risk variants are associated with atypical Alzheimer's disease.
Kim B et al.
Acta Neuropathologica, 2022
Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2.
Haure-Mirande JV et al.
Molecular Neurodegeneration, 2022
Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function.
Dash R et al.
Scientific Reports, 2022
TREM2 coding variants in Slovak Alzheimer's disease patients.
Durmanova V et al.
Journal of Integrative Neuroscience, 2022
Soluble TREM2: Innocent bystander or active player in neurological diseases?
Filipello F et al.
Neurobiology of Disease, 2022
Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
Belsare KD et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022
Microglial TREM2 in amyotrophic lateral sclerosis.
Xie M et al.
Developmental Neurobiology, 2022
TREM2 Gene Compound Heterozygosity in Neurodegenerative Disorders.
Berdyński M et al.
Journal of Alzheimer's Disease : Jad, 2022
Role of TREM2 in Alzheimer's Disease: A Long Road Ahead.
Kulkarni B et al.
Molecular Neurobiology, 2021
The most prevalent rare coding variants of TREM2 conferring risk of Alzheimer's disease: A systematic review and meta-analysis.
Li R et al.
Experimental and Therapeutic Medicine, 2021
African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants.
Schindler SE et al.
Neurology. Genetics, 2021
Insight into the genetic etiology of Alzheimer's disease: A comprehensive review of the role of rare variants.
Hoogmartens J et al.
Alzheimer's & Dementia (amsterdam, Netherlands), 2021
Systematic Review: Genetic, Neuroimaging, and Fluids Biomarkers for Frontotemporal Dementia Across Latin America Countries.
Duran-Aniotz C et al.
Frontiers in Neurology, 2021
Association of APOE With Primary Open-Angle Glaucoma Suggests a Protective Effect for APOE ε4.
Margeta MA et al.
Investigative Ophthalmology & Visual Science, 2020
Genetic factors related to the immune system in subjects at risk of developing Alzheimer's disease.
Prendecki M et al.
Journal of Integrative Neuroscience, 2020
Heterozygous TREM2 Mutation in Semantic Variant of Primary Progressive Aphasia.
Ji MJ et al.
Journal of Clinical Neurology (seoul, Korea), 2020
Mechanistic insights into the deleterious roles of Nasu-Hakola disease associated TREM2 variants.
Dash R et al.
Scientific Reports, 2020