Associated Papers
TREM2 Drives Neutrophil Extracellular Traps-Induced Dendritic Cell Maturation and Contributes to Lupus Progression.
Shu J et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2026
Sterile innate immune mechanisms in neurodegenerative diseases.
Ealy A et al.
The Journal of Biological Chemistry, 2026
Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers.
Jeskanen H et al.
Alzheimer's Research & Therapy, 2026
The TREM2 T96K paradox: Stronger signaling in vitro, weaker microglia in vivo.
Penati S et al.
Neuron, 2026
TREM2 activation by first-in-class direct small molecule agonists: DEL screening, optimization, biophysical validation, and functional characterization.
Nada H et al.
European Journal of Medicinal Chemistry, 2026
Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer's disease.
Asih PR et al.
Journal of Alzheimer's Disease : Jad, 2026
Alterations in the brain lipidome of Alzheimer's disease donors with rare TREM2 risk variants.
Proitsi P et al.
Brain Communications, 2026
As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition.
Cho S et al.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2025
Decoding Alzheimer's Disease: Single-Cell Sequencing Uncovers Brain Cell Heterogeneity and Pathogenesis.
Ma YN et al.
Molecular Neurobiology, 2025
Genetic testing of common and rare variants in dementia patients from a memory clinic : Dementia-related genetic testing in memory clinic.
de Rojas I et al.
Alzheimer's Research & Therapy, 2025
ApoE-calypse tau: ApoE-tau synergy in Alzheimer's disease.
Lennol MP et al.
The Journal of Experimental Medicine, 2025
Differential associations of APOE and TREM2 variants with glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants support distinct disease mechanisms.
Freudenberg-Hua Y et al.
Molecular Psychiatry, 2025
TREM2-apoE3 interactions and Alzheimer's disease: Molecular and structural insights and effects of TREM2 R47H and apoE4 variants.
Greer RA et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025
The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids.
Saeb D et al.
Elife, 2025
The TREM2 H157Y variant is associated with more severe neurodegeneration in Alzheimer's disease and altered immune-related processes.
Tsui JSM et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025
BrainGeneBot: a framework for variant prioritization and generative pretrained transformer-informed interpretation across polygenic risk score studies.
Qu G et al.
Briefings in Bioinformatics, 2025
As48, a First-in-Class Dual-Function TREM2 Modulator: Receptor Activation and Shedding Inhibition.
Cho S et al.
Biorxiv : the Preprint Server for Biology, 2025
Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.
Khani M et al.
Nature Communications, 2025
Neuroimaging-derived biological brain age and its associations with glial reactivity and synaptic dysfunction cerebrospinal fluid biomarkers.
Cumplido-Mayoral I et al.
Molecular Psychiatry, 2025
TREM2 in Neurodegenerative Disorders: Mutation Spectrum, Pathophysiology, and Therapeutic Targeting.
Yang H et al.
International Journal of Molecular Sciences, 2025
Glial Cells in Alzheimer's Disease: Pathogenic Mechanisms and Therapeutic Frontiers.
Sil M et al.
Journal of Molecular Neuroscience : Mn, 2025
Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions.
Giorgio J et al.
Nature Communications, 2025
Cytokines and immune biomarkers in neurodegeneration and cognitive function: A systematic review among individuals of African ancestry.
Antwi MH et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways.
Bradley J et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2025
TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization.
Nada H et al.
Biorxiv : the Preprint Server for Biology, 2025
Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research.
Jung ES et al.
Molecular Neurodegeneration, 2025
TREM2 risk variants and associated endophenotypes in alzheimer's disease.
Dijkstra JIR et al.
Alzheimer's Research & Therapy, 2025
APOE and TREM2 variants differentially influence glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants.
Freudenberg-Hua Y et al.
Medrxiv : the Preprint Server for Health Sciences, 2025
The Spectrum of Genetic Risk in Alzheimer Disease.
Karagas N et al.
Neurology. Genetics, 2025
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.
Greven JA et al.
Molecular Neurodegeneration, 2025
Predicting the impact of missense mutations on an unresolved protein's stability, structure, and function: A case study of Alzheimer's disease-associated TREM2 R47H variant.
Pillai J et al.
Computational and Structural Biotechnology Journal, 2025
Biophysical characterization of TREM2 missense variants implicated in neurodegenerative disease.
Pillai J et al.
Computational and Structural Biotechnology Journal, 2025
Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations.
Villegas-Llerena C et al.
Frontiers in Neuroscience, 2025
Plasticity of Human Microglia and Brain Perivascular Macrophages in Aging and Alzheimer's Disease.
Lee D et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
Pathophysiologic abnormalities in transgenic mice carrying the Alzheimer disease PSEN1 Δ440 mutation.
Fuller PE et al.
Human Molecular Genetics, 2024
AlzDiscovery: A computational tool to identify Alzheimer's disease-causing missense mutations using protein structure information.
Pan Q et al.
Protein Science : a Publication of the Protein Society, 2024
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands.
Greven JA et al.
Research Square, 2024
A Risk Variant rs6922617 in TREM Is Discrepantly Associated With Defining Neuropathological Hallmarks in the Alzheimer's Continuum.
Qian S et al.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2024
Multimerization of TREM2 is impaired by Alzheimer's disease-associated variants.
Dean HB et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2024
TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid.
McMillan IO et al.
The Journal of Biological Chemistry, 2024
Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions.
Giorgio J et al.
Research Square, 2024
TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing.
Kiianitsa K et al.
Brain : a Journal of Neurology, 2024
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways.
Cruchaga C et al.
Research Square, 2024