Varaico: Literature-Extracted Genetic Variants

Gene:TREX1
Variant:p.D200A
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TREX1

NM_033629.6:p.D200A

Associated Papers

Aicardi-Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion.

Li P et al.

Nucleic Acids Research, 2017

28334850 (PubMed )
Supplement: gkx178_Supp.pdf

Dominant mutation of the TREX1 exonuclease gene in lupus and Aicardi-Goutieres syndrome.

Fye JM et al.

The Journal of Biological Chemistry, 2011

Trex1 prevents cell-intrinsic initiation of autoimmunity.

Stetson DB et al.

Cell, 2008

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