Associated Papers
TREX1 exonuclease in immunity and disease.
Shang Z et al.
International Immunology, 2025
Prevalence and impact of molecular variation in the three-prime repair exonuclease 1 TREX1 and its implications for oncology.
Shekfeh M et al.
Human Genomics, 2025
40581636 (PubMed )
Supplement: 40246_2025_785_MOESM11_ESM.xlsx › Table_S8
The induction of type I interferonopathy in Trex1-P212fs mice is mediated by activation of the cGAS-STING pathway.
Du H et al.
International Journal of Biological Macromolecules, 2025
The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis.
Tever OK et al.
Cellular and Molecular Life Sciences : Cmls, 2025
The SLE-associated TREX1-P212fs mutation disrupts ER association leading to type I interferonopathy.
Xu S et al.
Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2024
Suppression of TREX1 deficiency-induced cellular senescence and interferonopathies by inhibition of DNA damage response.
Du H et al.
Iscience, 2023
RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA.
Wolf C et al.
Nature Communications, 2016
27230542 (PubMed )
Supplement: ncomms11752-s1.pdf
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.
Hasan M et al.
Immunity, 2015
Rare variants in the TREX1 gene and susceptibility to autoimmune diseases.
Barizzone N et al.
Biomed Research International, 2013
TREX1 gene variant in neuropsychiatric systemic lupus erythematosus.
de Vries B et al.
Annals of the Rheumatic Diseases, 2010
Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity.
Crow YJ et al.
Human Molecular Genetics, 2009
New roles for the major human 3'-5' exonuclease TREX1 in human disease.
Kavanagh D et al.
Cell Cycle (georgetown, Tex.), 2008
Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.
Lee-Kirsch MA et al.
Nature Genetics, 2007
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