Associated Papers
TRIB3 Links Endoplasmic Reticulum Stress to Impaired Efferocytosis in Atherosclerosis.
Singhal A et al.
Circulation Research, 2025
TRIB3 at the nexus of metabolic disorders: In-depth analysis of biochemical mechanisms and concepts for drug discovery.
Peng J et al.
Biochemical Pharmacology, 2025
Targeting the TRIB3-MYC axis in cancer: mechanistic insights and therapeutic disruption strategies.
Kamel EM et al.
Investigational New Drugs, 2025
TRIB3-TRIM8 complex drives NAFLD progression by regulating HNF4α stability.
Xiao MC et al.
Journal of Hepatology, 2024
TRIB3 promoter 33 bp VNTR is associated with the risk of cerebrovascular disease in type 2 diabetic patients.
Lai J et al.
Frontiers in Genetics, 2022
Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling.
Martinez-Campesino L et al.
Frontiers in Cardiovascular Medicine, 2022
The TRIB3 R84 variant is associated with increased left ventricular mass in a sample of 2426 White individuals.
Mannino GC et al.
Cardiovascular Diabetology, 2021
Two novel homozygous mutations in NPHP1 lead to late onset end-stage renal disease: a case report of an adult nephronophthisis in a Chinese intermarriage family.
Wang Y et al.
Bmc Nephrology, 2019
Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis.
Smyth LJ et al.
Bmj Open, 2019
Interaction of germline variants in a family with a history of early-onset clear cell renal cell carcinoma.
Nicolas E et al.
Molecular Genetics & Genomic Medicine, 2019
Polytropic Influence of TRIB3 rs2295490 Genetic Polymorphism on Response to Antihypertensive Agents in Patients With Essential Hypertension.
Zhou J et al.
Frontiers in Pharmacology, 2019
COL4A3 Gene Variants and Diabetic Kidney Disease in MODY.
Wang Y et al.
Clinical Journal of the American Society of Nephrology : Cjasn, 2018
Identification of nine genes as novel susceptibility loci for early-onset ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage.
Yamada Y et al.
Biomedical Reports, 2018
A Drosophila model of insulin resistance associated with the human TRIB3 Q/R polymorphism.
Fischer Z et al.
Disease Models & Mechanisms, 2017
Association of Increased Serum Sema3E with TRIB3 Q84R Polymorphism and Carotid Atherosclerosis in Metabolic Syndrome.
Qin RR et al.
Annals of Clinical and Laboratory Science, 2017
Tripping on TRIB3 at the junction of health, metabolic dysfunction and cancer.
Mondal D et al.
Biochimie, 2016
Is common genetic variation at IRS1, ENPP1 and TRIB3 loci associated with cardiometabolic phenotypes in type 2 diabetes? An exploratory analysis of the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 5.
Trombetta M et al.
Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd, 2016
The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations.
Prudente S et al.
Biochemical Society Transactions, 2015
Infrequent TRIB3 coding variants and coronary artery disease in type 2 diabetes.
Prudente S et al.
Atherosclerosis, 2015
Joint effect of insulin signaling genes on all-cause mortality.
Menzaghi C et al.
Atherosclerosis, 2014
Current Insights into the Joint Genetic Basis of Type 2 Diabetes and Coronary Heart Disease.
Dauriz M et al.
Current Cardiovascular Risk Reports, 2014
Joint effect of insulin signaling genes on insulin secretion and glucose homeostasis.
Prudente S et al.
The Journal of Clinical Endocrinology and Metabolism, 2013
Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance.
Bacci S et al.
Atherosclerosis, 2013
Variants of insulin-signaling inhibitor genes in type 2 diabetes and related metabolic abnormalities.
de Lorenzo C et al.
International Journal of Genomics, 2013
Decreased serum obestatin consequent upon TRIB3 Q84R polymorphism exacerbates carotid atherosclerosis in subjects with metabolic syndrome.
Cui AD et al.
Diabetology & Metabolic Syndrome, 2012
The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases.
Prudente S et al.
Endocrine Reviews, 2012
Developmental roles of tribbles protein family members.
Dobens LL et al.
Developmental Dynamics : an Official Publication of the American Association of Anatomists, 2012
The pancreatic beta cells in human type 2 diabetes.
Marchetti P et al.
Advances in Experimental Medicine and Biology, 2012
The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells.
Prudente S et al.
Atherosclerosis, 2011
ENPP1 affects insulin action and secretion: evidences from in vitro studies.
Di Paola R et al.
Plos One, 2011
Association of TRB3 Q84R polymorphism with polycystic ovary syndrome in Chinese women.
Zhang X et al.
Reproductive Biology and Endocrinology : Rb&e, 2011
The TRIB3 R84 variant is associated with increased carotid intima-media thickness in vivo and with enhanced MAPK signalling in human endothelial cells.
Formoso G et al.
Cardiovascular Research, 2011
[The -108 C/T polymorphism in paraoxonase 1 gene in Chinese patients with polycystic ovary syndrome].
Zhang F et al.
Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition, 2011
The porcine tribbles homolog 3 (TRIB3) gene: Identification of a missense mutation and association analysis with meat quality and production traits in Italian heavy pigs.
Fontanesi L et al.
Meat Science, 2010
The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.
Liew CW et al.
The Journal of Clinical Investigation, 2010
TRIB3 R84 variant affects glucose homeostasis by altering the interplay between insulin sensitivity and secretion.
Prudente S et al.
Diabetologia, 2010
Insulin signaling regulating genes: effect on T2DM and cardiovascular risk.
Prudente S et al.
Nature Reviews. Endocrinology, 2009
ENPP1 Q121 variant, increased pulse pressure and reduced insulin signaling, and nitric oxide synthase activity in endothelial cells.
Bacci S et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
TRIB3 functional Q84R polymorphism is a risk factor for metabolic syndrome and carotid atherosclerosis.
Gong HP et al.
Diabetes Care, 2009
The emerging role of TRIB3 as a gene affecting human insulin resistance and related clinical outcomes.
Prudente S et al.
Acta Diabetologica, 2009
Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population.
Shi Z et al.
Endocrine, 2009
The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes.
Prudente S et al.
The Journal of Clinical Endocrinology and Metabolism, 2009
TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells.
Andreozzi F et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2008
Double tribble: two TRIB3 variants, insulin, Akt, and eNOS.
Fleming I
Arteriosclerosis, Thrombosis, and Vascular Biology, 2008
Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes.
De Cosmo S et al.
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 2007
The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.
Prudente S et al.
Diabetes, 2005