Associated Papers
E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling.
Han T et al.
Jci Insight, 2026
Oxidized ATM governs stemness of breast cancer stem cell through regulating ubiquitylation and acetylation switch.
Zhou X et al.
Biochemical and Biophysical Research Communications, 2024
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
Yang C et al.
Autophagy, 2023
TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models.
Li JY et al.
Nature Communications, 2023
E3 ubiquitin ligase TRIM21 targets TIF1γ to regulate β-catenin signaling in glioblastoma.
Li Y et al.
Theranostics, 2023
TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination.
Zhu X et al.
Nucleic Acids Research, 2022
CSN6-TRIM21 axis instigates cancer stemness during tumorigenesis.
Qin B et al.
British Journal of Cancer, 2020
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
Li Z et al.
Embo Reports, 2020
Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis.
Lee JH et al.
Nature Communications, 2017
TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis.
Pan JA et al.
Molecular Cell, 2016
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