Associated Papers
ZDHHC20-mediated S-palmitoylation of KAP1/TRIM28 promotes DNA damage repair.
Liu Z et al.
Oncogene, 2025
An eRNA transcription checkpoint for diverse signal-dependent enhancer activation programs.
Wang L et al.
Nature Genetics, 2025
OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1S824.
Lam SY et al.
Nature Communications, 2024
UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair.
Xu N et al.
Investigative Ophthalmology & Visual Science, 2022
HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia.
Yang Y et al.
Nature Communications, 2022
Disruption of RING and PHD Domains of TRIM28 Evokes Differentiation in Human iPSCs.
Mazurek S et al.
Cells, 2021
ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming.
Liu X et al.
Cancer Research, 2020
ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.
Jaiswal H et al.
The Embo Journal, 2017
KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair.
Lin YH et al.
Plos One, 2015
TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release.
Bunch H et al.
Nature Structural & Molecular Biology, 2014
An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.
Kuo CY et al.
The Journal of Biological Chemistry, 2014
Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis.
Kim H et al.
Molecular Cell, 2014
MAGE-C2 promotes growth and tumorigenicity of melanoma cells, phosphorylation of KAP1, and DNA damage repair.
Bhatia N et al.
The Journal of Investigative Dermatology, 2013
Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair.
Pinder JB et al.
Frontiers in Genetics, 2013
ATM release at resected double-strand breaks provides heterochromatin reconstitution to facilitate homologous recombination.
Geuting V et al.
Plos Genetics, 2013
Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks.
Liu J et al.
Cell Cycle (georgetown, Tex.), 2012
Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response.
Hu C et al.
The Journal of Biological Chemistry, 2012
Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.
Lee DH et al.
The Embo Journal, 2012
The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation.
White D et al.
Molecular Cancer Research : Mcr, 2012
KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.
Goodarzi AA et al.
Nature Structural & Molecular Biology, 2011
KAP1 depletion increases PML nuclear body number in concert with ultrastructural changes in chromatin.
Kepkay R et al.
Cell Cycle (georgetown, Tex.), 2011
The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.
Goodarzi AA et al.
Dna Repair, 2010
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
Noon AT et al.
Nature Cell Biology, 2010
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression.
Li X et al.
The Journal of Biological Chemistry, 2007
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
Ziv Y et al.
Nature Cell Biology, 2006
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography.
Thompson LH
Mutation Research, 0