Varaico: Literature-Extracted Genetic Variants

Gene:TRIM5
Variant:p.R136Q
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TRIM5

NM_033034.3:p.R136Q

Associated Papers

The effect of TRIM5 variants on the susceptibility to HIV-1 infection and disease progression in the Polish population.

Bratosiewicz-Wąsik J et al.

Annals of Human Genetics, 2024

High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies.

Toulmonde M et al.

Ebiomedicine, 2020

33254023 (PubMed )
Supplement: mmc5.xlsx › UPS_somatic_mutations_filtered

IMPLICATION OF FIVE AIDS RELATED GENES IN MOTHER-TO-CHILD TRANSMISSION AND ACQUISITION OF HUMAN IMMUNODEFICIENCY VIRUS 1 IN CAMEROON.

Mekue LM et al.

African Journal of Infectious Diseases, 2019

Impact of cellular restriction gene (TRIM5α, BST-2) polymorphisms on the acquisition of HIV-1 and disease progression.

Singh H et al.

The Journal of Gene Medicine, 2018

TRIM5 gene polymorphisms in HIV-1-infected patients and healthy controls from Northeastern Brazil.

Celerino da Silva R et al.

Immunologic Research, 2016

The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data.

Tang X et al.

Nucleic Acids Research, 2014

25352556 (PubMed )
Supplement: supp_gku1005_nar-01266-met-n-2014-File012.xlsx › TCGA-A2-A0EM-01A.domain

Clonal evolution in breast cancer revealed by single nucleus genome sequencing.

Wang Y et al.

Nature, 2014

25079324 (PubMed )
Supplement: NIHMS607979-supplement-1.pdf

In silico analysis of functional single nucleotide polymorphisms in the human TRIM22 gene.

Kelly JN et al.

Plos One, 2014

Susceptibility and adaptation to human TRIM5α alleles at positive selected sites in HIV-1 capsid.

Rahm N et al.

Virology, 2013

A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV type 1 activity and susceptibility to HIV type 1 infection.

Nakayama EE et al.

Aids Research and Human Retroviruses, 2013

The genetic basis of resistance to HIV infection and disease progression.

Biasin M et al.

Expert Review of Clinical Immunology, 2013

Evidence for selection at HIV host susceptibility genes in a West Central African human population.

Zhao K et al.

Bmc Evolutionary Biology, 2012

An HIV-1 resistance polymorphism in TRIM5α gene among Chinese intravenous drug users.

Liu FL et al.

Journal of Acquired Immune Deficiency Syndromes (1999), 2011

Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 gene.

Cagliani R et al.

Human Genetics, 2010

Inhibitory effect of human TRIM5alpha on HIV-1 production.

Zhang X et al.

Microbes and Infection, 2010

A TRIM5alpha exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort.

Price H et al.

Aids (london, England), 2010

Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination.

Ovsyannikova IG et al.

The Journal of Infectious Diseases, 2010

Impact of novel TRIM5alpha variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection.

Nakajima T et al.

Aids (london, England), 2009

A rare null allele potentially encoding a dominant-negative TRIM5alpha protein in Baka pygmies.

Torimiro JN et al.

Virology, 2009

Genetic determinants of HIV-1 infection and progression to AIDS: susceptibility to HIV infection.

Kaur G et al.

Tissue Antigens, 2009

Interpreting missense mutations in Human TRIM5alpha by computational methods.

Chan PA

Bmc Research Notes, 2008

The presence of the Trim5alpha escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase.

Kootstra NA et al.

Aids (london, England), 2007

Regulatory polymorphisms in the cyclophilin A gene, PPIA, accelerate progression to AIDS.

An P et al.

Plos Pathogens, 2007

Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection.

Javanbakht H et al.

Virology, 2006

Role of common human TRIM5alpha variants in HIV-1 disease progression.

Goldschmidt V et al.

Retrovirology, 2006

Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection.

Speelmon EC et al.

Journal of Virology, 2006

High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans.

Sawyer SL et al.

Current Biology : Cb, 2006

Predicting nsSNPs that Disrupt Protein-Protein Interactions Using Docking.

Goodacre N et al.

Ieee/acm Transactions on Computational Biology and Bioinformatics, 0

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