Varaico: Literature-Extracted Genetic Variants

Gene:TRIP13
Variant:p.E253Q
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TRIP13

NM_004237.4:p.E253Q

Associated Papers

TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11.

Jeong H et al.

Cells, 2022

MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.

de Krijger I et al.

Nature Communications, 2021

Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex.

Xie W et al.

Proceedings of the National Academy of Sciences of the United States of America, 2021

Thyroid receptor-interacting protein 13 and EGFR form a feedforward loop promoting glioblastoma growth.

Hu L et al.

Cancer Letters, 2020

PCH-2 collaborates with CMT-1 to proofread meiotic homolog interactions.

Giacopazzi S et al.

Plos Genetics, 2020

TRIP13 regulates DNA repair pathway choice through REV7 conformational change.

Clairmont CS et al.

Nature Cell Biology, 2020

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.

Alfieri C et al.

Nature, 2018

The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.

Ye Q et al.

The Embo Journal, 2017

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching.

Ye Q et al.

Elife, 2015

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."