Associated Papers
Small fiber neuropathy: expanding diagnosis with unsettled etiology.
Devigili G et al.
Current Opinion in Neurology, 2025
Functional dynamics and allosteric modulation of TRPA1.
Koldsø H et al.
Structure (london, England : 1993), 2023
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity.
Faux P et al.
Communications Biology, 2023
TRPA1 rare variants in chronic neuropathic and nociplastic pain patients.
Marchi M et al.
Pain, 2023
Molecular mechanism of hyperactivation conferred by a truncation of TRPA1.
Bali A et al.
Nature Communications, 2023
Expanding the genetic causes of small-fiber neuropathy: SCN genes and beyond.
Chan ACY et al.
Muscle & Nerve, 2023
Investigating genotype-phenotype relationship of extreme neuropathic pain disorders in a UK national cohort.
Themistocleous AC et al.
Brain Communications, 2023
In silico analysis of TRPM4 variants of unknown clinical significance.
Tarnovskaya SI et al.
Plos One, 2023
Peripheral Ion Channel Genes Screening in Painful Small Fiber Neuropathy.
Ślęczkowska M et al.
International Journal of Molecular Sciences, 2022
Peripheral Ion Channel Gene Screening in Painful- and Painless-Diabetic Neuropathy.
Ślęczkowska M et al.
International Journal of Molecular Sciences, 2022
Atomistic mechanisms of human TRPA1 activation by electrophile irritants through molecular dynamics simulation and mutual information analysis.
Habgood M et al.
Scientific Reports, 2022
TRP channels in health and disease at a glance.
Yue L et al.
Journal of Cell Science, 2021
TRPA1 gene variants hurting our feelings.
Naert R et al.
Pflugers Archiv : European Journal of Physiology, 2020
Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Suo Y et al.
Neuron, 2020
Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response.
Recla JM et al.
Pain, 2019
Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids.
Riehle M et al.
Naunyn-schmiedeberg's Archives of Pharmacology, 2018
Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS.
Miyake T et al.
Nature Communications, 2016
Characterization of Disease-Associated Mutations in Human Transmembrane Proteins.
Molnár J et al.
Plos One, 2016
Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma.
Deering-Rice CE et al.
American Journal of Respiratory Cell and Molecular Biology, 2015
How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy.
Brewster MS et al.
Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology, 2015
Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.
Morgan K et al.
Bioscience Reports, 2015
Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state.
Zíma V et al.
Neuropharmacology, 2015
Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor.
Morgan K et al.
Bioscience Reports, 2014
Gain-of-function mutations in the transient receptor potential channels TRPV1 and TRPA1: how painful?
Boukalova S et al.
Physiological Research, 2014
Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain.
Zayats V et al.
Journal of Molecular Modeling, 2013
Differential expression and functionality of TRPA1 protein genetic variants in conditions of thermal stimulation.
May D et al.
The Journal of Biological Chemistry, 2012
C-terminal acidic cluster is involved in Ca2+-induced regulation of human transient receptor potential ankyrin 1 channel.
Sura L et al.
The Journal of Biological Chemistry, 2012
Pharmacogenetics of new analgesics.
Lötsch J et al.
British Journal of Pharmacology, 2011
Genetic variability of pain perception and treatment--clinical pharmacological implications.
Lötsch J
European Journal of Clinical Pharmacology, 2011
A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome.
Kremeyer B et al.
Neuron, 2010