Varaico: Literature-Extracted Genetic Variants

Gene:TSC2
Variant:p.T1422A
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TSC2

NM_000548.5:p.T1422A

Associated Papers

14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin.

Shumway SD et al.

The Journal of Biological Chemistry, 2003

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.

Inoki K et al.

Nature Cell Biology, 2002

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."