Associated Papers
The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction.
Yang S et al.
Developmental Cell, 2020
Differential IKK/NF-κB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate Cancer and Tuberous Sclerosis Complex Tumor Cells.
Gao Y et al.
Molecular Cancer Research : Mcr, 2015
The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.
Block K et al.
The American Journal of Pathology, 2010
Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes.
Miyazaki M et al.
The Febs Journal, 2010
The tuberous sclerosis complex.
Orlova KA et al.
Annals of the New York Academy of Sciences, 2010
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.
Zhang HH et al.
Plos One, 2009
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
Huang J et al.
The Biochemical Journal, 2008
p27Kip1 localization depends on the tumor suppressor protein tuberin.
Rosner M et al.
Human Molecular Genetics, 2007
Akt regulates nuclear/cytoplasmic localization of tuberin.
Rosner M et al.
Oncogene, 2007
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
Cai SL et al.
The Journal of Cell Biology, 2006
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
Ma L et al.
Cell, 2005
Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B.
Astrinidis A et al.
The Journal of Biological Chemistry, 2003
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin.
Tee AR et al.
The Journal of Biological Chemistry, 2003
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
Manning BD et al.
Molecular Cell, 2002
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