Varaico: Literature-Extracted Genetic Variants

Gene:TSHR
Variant:p.E251A
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TSHR

NM_000369.5:p.E251A

Associated Papers

Novel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptor.

Chen CR et al.

Plos One, 2012

Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation.

Chen CR et al.

Endocrinology, 2010

Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: a comparative structural study of protein-protein interactions.

Núñez Miguel R et al.

Journal of Molecular Endocrinology, 2009

FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity.

Núñez Miguel R et al.

Journal of Molecular Endocrinology, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."