Varaico: Literature-Extracted Genetic Variants

Gene:TSHR
Variant:p.D633N
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TSHR

NM_000369.5:p.D633N

Associated Papers

Predicting Pathogenicity of TSHR Missense Variants of Uncertain Significance: An Integrative Computational Study.

Hajali TA et al.

International Journal of Molecular Sciences, 2026

41684033 (PubMed )
Supplement: ijms-27-01614-s001.zip › ijms-4117947-supplementary.pdf

Targeted Next-Generation Sequencing Identifies Actionable Targets in Estrogen Receptor Positive and Estrogen Receptor Negative Endometriod Endometrial Cancer.

Suhaimi SS et al.

Frontiers in Pharmacology, 2018

30057548 (PubMed )
Supplement: Data_Sheet_1.xls › Supplementary_Table_S5

GRIS: glycoprotein-hormone receptor information system.

Van Durme J et al.

Molecular Endocrinology (baltimore, Md.), 2006

A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation.

Neumann S et al.

Molecular Endocrinology (baltimore, Md.), 2001

A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.

Govaerts C et al.

The Journal of Biological Chemistry, 2001

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."