Varaico: Literature-Extracted Genetic Variants

Gene:TSHR
Variant:p.Y643F
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TSHR

NM_000369.5:p.Y643F

Associated Papers

Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain.

Marcinkowski P et al.

Molecular Pharmacology, 2019

Molecular sampling of the allosteric binding pocket of the TSH receptor provides discriminative pharmacophores for antagonist and agonists.

Hoyer I et al.

Biochemical Society Transactions, 2013

Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.

Haas AK et al.

Cellular and Molecular Life Sciences : Cmls, 2011

Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.

Kleinau G et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2010

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."