Associated Papers
Impaired IL-23-dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency.
Ogishi M et al.
The Journal of Experimental Medicine, 2022
TYK2 Variants in B-Acute Lymphoblastic Leukaemia.
Turrubiartes-Martínez E et al.
Genes, 2020
Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage.
Li Z et al.
Plos One, 2020
Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant.
Boisson-Dupuis S et al.
Science Immunology, 2018
Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene.
Leitner NR et al.
Cytokine, 2017
Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).
Min X et al.
The Journal of Biological Chemistry, 2015
TYK2 activity promotes ligand-induced IFNAR1 proteolysis.
Marijanovic Z et al.
The Biochemical Journal, 2006
Interferon alpha activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway.
Yang CH et al.
The Journal of Biological Chemistry, 2005
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