Varaico: Literature-Extracted Genetic Variants

Gene:TYMP
Variant:p.G412G
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TYMP

NM_001953.5:p.G412G

Associated Papers

DPYD genotype-guided dose personalisation for fluoropyrimidine-based chemotherapy prescribing in solid organ cancer patients in Australia: GeneScreen 5-FU study protocol.

White C et al.

Bmc Cancer, 2024

Novel Genetic Variants Explaining Severe Adverse Drug Events after Clinical Implementation of DPYD Genotype-Guided Therapy with Fluoropyrimidines: An Observational Study.

Díaz-Villamarín X et al.

Pharmaceutics, 2024

Influence of Single-Nucleotide Polymorphisms on Clinical Outcomes of Capecitabine-Based Chemotherapy in Colorectal Cancer Patients: A Systematic Review.

Cura Y et al.

Cancers, 2023

Current diagnostic and clinical issues of screening for dihydropyrimidine dehydrogenase deficiency.

Etienne-Grimaldi MC et al.

European Journal of Cancer (oxford, England : 1990), 2023

Dihydropyrimidine Dehydrogenase Deficiency and Implementation of Upfront DPYD Genotyping.

White C et al.

Clinical Pharmacology and Therapeutics, 2022

Dihydropyrimidine dehydrogenase (DPD) polymorphisms knocking on the door.

Donadio MDS et al.

Ecancermedicalscience, 2022

Pharmacogenetic profiling of dihydropyrimidine dehydrogenase (DPYD) variants in the Indian population.

Naushad SM et al.

The Journal of Gene Medicine, 2021

Ethnic Diversity of DPD Activity and the DPYD Gene: Review of the Literature.

White C et al.

Pharmacogenomics and Personalized Medicine, 2021

The use of pharmacogenetics to increase the safety of colorectal cancer patients treated with fluoropyrimidines.

De Mattia E et al.

Cancer Drug Resistance (alhambra, Calif.), 2019

Tailored therapy in patients treated with fluoropyrimidines: focus on the role of dihydropyrimidine dehydrogenase.

Merloni F et al.

Cancer Drug Resistance (alhambra, Calif.), 2019

Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines.

Jennings BA et al.

Plos One, 2013

Severe fluoropyrimidine-related toxicity: clinical implications of DPYD analysis and UH2/U ratio evaluation.

Giorgio E et al.

Cancer Chemotherapy and Pharmacology, 2011

Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in a cohort of Caucasian individuals.

Seck K et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."