Varaico: Literature-Extracted Genetic Variants

Gene:TYMS
Variant:p.R50C
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TYMS

NM_001071.4:p.R50C

Associated Papers

Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers.

Siddiqui A et al.

Cell Death and Differentiation, 2019

Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme.

Rahman L et al.

Cancer Cell, 2004

Examination of the reduced affinity of the thymidylate synthase G52S mutation for FdUMP by ab initio and semi-empirical studies.

Sapse AM et al.

Molecular Medicine (cambridge, Mass.), 2001

Protection of bone marrow cells from toxicity of chemotherapeutic agents targeted toward thymidylate synthase by transfer of mutant forms of human thymidylate synthase cDNA.

Banerjee D et al.

Progress in Experimental Tumor Research, 1999

Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells.

Tong Y et al.

The Journal of Biological Chemistry, 1998

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."