Associated Papers
Molecularly evolved thymidylate synthase inhibits 5-fluorodeoxyuridine toxicity in human hematopoietic cells.
Bielas JH et al.
Human Gene Therapy, 2009
Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil.
Capiaux GM et al.
Human Gene Therapy, 2003
Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine.
Kawate H et al.
The Journal of Biological Chemistry, 2002
Examination of the reduced affinity of the thymidylate synthase G52S mutation for FdUMP by ab initio and semi-empirical studies.
Sapse AM et al.
Molecular Medicine (cambridge, Mass.), 2001
Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase.
Landis DM et al.
Cancer Research, 2001
Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Fantz C et al.
Molecular Pharmacology, 2000
Protection of bone marrow cells from toxicity of chemotherapeutic agents targeted toward thymidylate synthase by transfer of mutant forms of human thymidylate synthase cDNA.
Banerjee D et al.
Progress in Experimental Tumor Research, 1999
Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells.
Tong Y et al.
The Journal of Biological Chemistry, 1998
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