Varaico: Literature-Extracted Genetic Variants

Gene:TYMS
Variant:p.P303L
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TYMS

NM_001071.4:p.P303L

Associated Papers

Functional dissection of the N-terminal degron of human thymidylate synthase.

Melo SP et al.

The Biochemical Journal, 2010

Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase.

Peña MM et al.

The Biochemical Journal, 2006

Structural determinants for the intracellular degradation of human thymidylate synthase.

Forsthoefel AM et al.

Biochemistry, 2004

Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine.

Kawate H et al.

The Journal of Biological Chemistry, 2002

Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase.

Landis DM et al.

Cancer Research, 2001

Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.

Fantz C et al.

Molecular Pharmacology, 2000

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."