Associated Papers
Engineering Forward Genetics into Cultured Cancer Cells for Chemical Target Identification.
Povedano JM et al.
Cell Chemical Biology, 2019
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.
Han T et al.
Science (new York, N.y.), 2017
Molecular dynamics investigation on the poor sensitivity of A171T mutant NEDD8-activating enzyme (NAE) for MLN4924.
Verma S et al.
Journal of Biomolecular Structure & Dynamics, 2014
Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.
Xu GW et al.
Plos One, 2014
A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924.
Toth JI et al.
Cell Reports, 2012
Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.
Milhollen MA et al.
Cancer Cell, 2012
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