Associated Papers
The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth.
Cai Z et al.
Neural Regeneration Research, 2026
OCTN2 Activates a Non-Canonical Carnitine Metabolic Pathway to Promote MASH-HCC Progression and Immunotherapy Resistance.
Xia C et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2026
Functional landscape of ubiquitin linkages couples K29-linked ubiquitylation to epigenome integrity.
Arroyo-Gomez J et al.
The Embo Journal, 2025
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.
Li W et al.
The Embo Journal, 2025
Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.
Carrillo Roas S et al.
Molecular Cell, 2025
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Hao X et al.
The Embo Journal, 2025
Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation.
Yoshida Y et al.
Molecular Cell, 2024
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.
Waltho A et al.
Life Science Alliance, 2024
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs.
Yang S et al.
Molecular Cell, 2024
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.
Hehl LA et al.
Nature Chemical Biology, 2024
PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.
Chou MC et al.
Molecular Cell, 2023
The E3 ubiquitin ligase CHIP drives monoubiquitylation-mediated nuclear import of the tumor suppressor PTEN.
Chakraborty S et al.
Journal of Cell Science, 2023
Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.
Hussain M et al.
The Journal of Biological Chemistry, 2023
Orphan quality control shapes network dynamics and gene expression.
Mark KG et al.
Cell, 2023
RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3β-FBXW7 cascade.
Oei V et al.
Communications Biology, 2023
Lipid kinase PIP5Kα contributes to Hippo pathway activation via interaction with Merlin and by mediating plasma membrane targeting of LATS1.
Le TPH et al.
Cell Communication and Signaling : Ccs, 2023
CDK1-cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry.
Chen NP et al.
Nature Cell Biology, 2022
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.
Nakagawa T et al.
Cell Reports, 2022
K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy.
Wang YT et al.
Cell Reports, 2022
Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase.
Ji Z et al.
Molecular Cell, 2022
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Linares JF et al.
Molecular Cell, 2021
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination.
Zhang L et al.
Cell Reports, 2021
A20 Inhibits LPS-Induced Inflammation by Regulating TRAF6 Polyubiquitination in Rainbow Trout.
Jang JH et al.
International Journal of Molecular Sciences, 2021
TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.
Zhu G et al.
Nature Cell Biology, 2021
TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.
Fan W et al.
Cell, 2021
NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Ju MK et al.
Nucleic Acids Research, 2021
The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63-branched ubiquitin chains.
Pluska L et al.
The Embo Journal, 2021
MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.
Hussain M et al.
Plos Biology, 2021
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.
Gallina I et al.
Molecular Cell, 2021
DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks.
Saha S et al.
Cell Reports, 2020
Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination.
Langerová H et al.
Cells, 2020
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Nakazawa Y et al.
Cell, 2020
STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection.
Wang W et al.
Plos Pathogens, 2020
The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates.
Martinez-Fonts K et al.
Nature Communications, 2020
Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex.
Masuda Y et al.
The Journal of Biological Chemistry, 2019
Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.
Clijsters L et al.
Molecular Cell, 2019
Rapid degradation of progressive ankylosis protein (ANKH) in craniometaphyseal dysplasia.
Kanaujiya J et al.
Scientific Reports, 2018
BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.
Priyadarshini R et al.
Cell Reports, 2018
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.
Yau RG et al.
Cell, 2017
Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.
Garreau A et al.
Journal of Immunology (baltimore, Md. : 1950), 2017
Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25.
Yang Y et al.
Biophysical Journal, 2017
Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy.
Feng L et al.
Autophagy, 2017
TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.
Wang X et al.
The Journal of Biological Chemistry, 2015
Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.
Choi YS et al.
The Journal of Biological Chemistry, 2015
Systematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeast.
Roscoe BP et al.
Journal of Molecular Biology, 2014