Associated Papers
The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth.
Cai Z et al.
Neural Regeneration Research, 2026
Functional landscape of ubiquitin linkages couples K29-linked ubiquitylation to epigenome integrity.
Arroyo-Gomez J et al.
The Embo Journal, 2025
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Hao X et al.
The Embo Journal, 2025
Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation.
Yoshida Y et al.
Molecular Cell, 2024
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.
Waltho A et al.
Life Science Alliance, 2024
The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes.
Saha S et al.
Nature Communications, 2023
Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.
Hussain M et al.
The Journal of Biological Chemistry, 2023
Orphan quality control shapes network dynamics and gene expression.
Mark KG et al.
Cell, 2023
HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.
Zhang G et al.
British Journal of Cancer, 2022
E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Ravichandran KE et al.
The Embo Journal, 2022
Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes.
Simões V et al.
Cell Reports, 2022
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.
Nakagawa T et al.
Cell Reports, 2022
K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy.
Wang YT et al.
Cell Reports, 2022
Differential Degradation of TRA2A and PYCR2 Mediated by Ubiquitin E3 Ligase E4B.
Lu Y et al.
Frontiers in Cell and Developmental Biology, 2022
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Linares JF et al.
Molecular Cell, 2021
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination.
Zhang L et al.
Cell Reports, 2021
A20 Inhibits LPS-Induced Inflammation by Regulating TRAF6 Polyubiquitination in Rainbow Trout.
Jang JH et al.
International Journal of Molecular Sciences, 2021
NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Ju MK et al.
Nucleic Acids Research, 2021
MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.
Hussain M et al.
Plos Biology, 2021
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.
Gallina I et al.
Molecular Cell, 2021
Structural basis for the multi-activity factor Rad5 in replication stress tolerance.
Shen M et al.
Nature Communications, 2021
DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks.
Saha S et al.
Cell Reports, 2020
KEAP1 Mutations Drive Tumorigenesis by Suppressing SOX9 Ubiquitination and Degradation.
Shao N et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2020
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Nakazawa Y et al.
Cell, 2020
STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection.
Wang W et al.
Plos Pathogens, 2020
Vangl2 interaction plays a role in the proteasomal degradation of Prickle2.
Nagaoka T et al.
Scientific Reports, 2019
Ubiquitin Chains Bearing Genetically Encoded Photo-Cross-Linkers Enable Efficient Covalent Capture of (Poly)ubiquitin-Binding Domains.
Braxton CN et al.
Biochemistry, 2019
BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.
Priyadarshini R et al.
Cell Reports, 2018
Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.
Nakasone MA et al.
Structure (london, England : 1993), 2017
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.
Yau RG et al.
Cell, 2017
TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.
Wang X et al.
The Journal of Biological Chemistry, 2015
Extended ubiquitin species are protein-based DUB inhibitors.
Krutauz D et al.
Nature Chemical Biology, 2014
RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.
Ramaekers CH et al.
Plos One, 2014
The TREX1 C-terminal region controls cellular localization through ubiquitination.
Orebaugh CD et al.
The Journal of Biological Chemistry, 2013
The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.
Moreno D et al.
Molecular Biology of the Cell, 2010
Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.
Tank EM et al.
Plos Genetics, 2009
The ubiquitin-proteasome system in spongiform degenerative disorders.
Whatley BR et al.
Biochimica Et Biophysica Acta, 2008
Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity.
Langie SA et al.
Dna Repair, 2007
Sensitivity of mammalian cells expressing mutant ubiquitin to protein-damaging agents.
Tsirigotis M et al.
The Journal of Biological Chemistry, 2001
Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain.
Spence J et al.
Cell, 2000
A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae.
Fisk HA et al.
The Journal of Cell Biology, 1999