Associated Papers
The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth.
Cai Z et al.
Neural Regeneration Research, 2026
Functional landscape of ubiquitin linkages couples K29-linked ubiquitylation to epigenome integrity.
Arroyo-Gomez J et al.
The Embo Journal, 2025
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Hao X et al.
The Embo Journal, 2025
Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation.
Yoshida Y et al.
Molecular Cell, 2024
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.
Waltho A et al.
Life Science Alliance, 2024
The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes.
Saha S et al.
Nature Communications, 2023
Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.
Hussain M et al.
The Journal of Biological Chemistry, 2023
Orphan quality control shapes network dynamics and gene expression.
Mark KG et al.
Cell, 2023
HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.
Zhang G et al.
British Journal of Cancer, 2022
E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
Ravichandran KE et al.
The Embo Journal, 2022
Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes.
Simões V et al.
Cell Reports, 2022
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.
Nakagawa T et al.
Cell Reports, 2022
K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy.
Wang YT et al.
Cell Reports, 2022
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Linares JF et al.
Molecular Cell, 2021
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination.
Zhang L et al.
Cell Reports, 2021
A20 Inhibits LPS-Induced Inflammation by Regulating TRAF6 Polyubiquitination in Rainbow Trout.
Jang JH et al.
International Journal of Molecular Sciences, 2021
NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Ju MK et al.
Nucleic Acids Research, 2021
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.
Fujino T et al.
Nature Communications, 2021
MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.
Hussain M et al.
Plos Biology, 2021
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.
Gallina I et al.
Molecular Cell, 2021
Structural basis for the multi-activity factor Rad5 in replication stress tolerance.
Shen M et al.
Nature Communications, 2021
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Nakazawa Y et al.
Cell, 2020
A negative feedback mechanism links UBC gene expression to ubiquitin levels by affecting RNA splicing rather than transcription.
Bianchi M et al.
Scientific Reports, 2019
BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.
Priyadarshini R et al.
Cell Reports, 2018
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.
Yau RG et al.
Cell, 2017
TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.
Wang X et al.
The Journal of Biological Chemistry, 2015
TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems.
Wynne C et al.
Plos One, 2014
Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling.
An L et al.
Scientific Reports, 2013
Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.
Tank EM et al.
Plos Genetics, 2009