Associated Papers
The Cullin3-Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth.
Cai Z et al.
Neural Regeneration Research, 2026
OCTN2 Activates a Non-Canonical Carnitine Metabolic Pathway to Promote MASH-HCC Progression and Immunotherapy Resistance.
Xia C et al.
Advanced Science (weinheim, Baden-wurttemberg, Germany), 2026
Functional landscape of ubiquitin linkages couples K29-linked ubiquitylation to epigenome integrity.
Arroyo-Gomez J et al.
The Embo Journal, 2025
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.
Li W et al.
The Embo Journal, 2025
Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.
Carrillo Roas S et al.
Molecular Cell, 2025
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Hao X et al.
The Embo Journal, 2025
Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation.
Yoshida Y et al.
Molecular Cell, 2024
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.
Waltho A et al.
Life Science Alliance, 2024
The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs.
Yang S et al.
Molecular Cell, 2024
Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.
Hehl LA et al.
Nature Chemical Biology, 2024
The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes.
Saha S et al.
Nature Communications, 2023
PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.
Chou MC et al.
Molecular Cell, 2023
The E3 ubiquitin ligase CHIP drives monoubiquitylation-mediated nuclear import of the tumor suppressor PTEN.
Chakraborty S et al.
Journal of Cell Science, 2023
Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.
Hussain M et al.
The Journal of Biological Chemistry, 2023
Orphan quality control shapes network dynamics and gene expression.
Mark KG et al.
Cell, 2023
RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3β-FBXW7 cascade.
Oei V et al.
Communications Biology, 2023
Lipid kinase PIP5Kα contributes to Hippo pathway activation via interaction with Merlin and by mediating plasma membrane targeting of LATS1.
Le TPH et al.
Cell Communication and Signaling : Ccs, 2023
HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.
Zhang G et al.
British Journal of Cancer, 2022
CDK1-cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry.
Chen NP et al.
Nature Cell Biology, 2022
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.
Nakagawa T et al.
Cell Reports, 2022
K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy.
Wang YT et al.
Cell Reports, 2022
Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase.
Ji Z et al.
Molecular Cell, 2022
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Linares JF et al.
Molecular Cell, 2021
Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination.
Zhang L et al.
Cell Reports, 2021
Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Abdul Rehman SA et al.
Molecular Cell, 2021
A20 Inhibits LPS-Induced Inflammation by Regulating TRAF6 Polyubiquitination in Rainbow Trout.
Jang JH et al.
International Journal of Molecular Sciences, 2021
TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity.
Fan W et al.
Cell, 2021
NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Ju MK et al.
Nucleic Acids Research, 2021
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.
Fujino T et al.
Nature Communications, 2021
The UBA domain of conjugating enzyme Ubc1/Ube2K facilitates assembly of K48/K63-branched ubiquitin chains.
Pluska L et al.
The Embo Journal, 2021
MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.
Hussain M et al.
Plos Biology, 2021
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.
Gallina I et al.
Molecular Cell, 2021
Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination.
Langerová H et al.
Cells, 2020
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Nakazawa Y et al.
Cell, 2020
Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex.
Masuda Y et al.
The Journal of Biological Chemistry, 2019
Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis.
Lee JG et al.
Biochemical and Biophysical Research Communications, 2018
BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.
Priyadarshini R et al.
Cell Reports, 2018
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.
Yau RG et al.
Cell, 2017
Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.
Garreau A et al.
Journal of Immunology (baltimore, Md. : 1950), 2017
MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.
Abdul Rehman SA et al.
Molecular Cell, 2016
TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.
Wang X et al.
The Journal of Biological Chemistry, 2015
Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities.
Choi YS et al.
The Journal of Biological Chemistry, 2015
Binding of HIV-1 Vpr protein to the human homolog of the yeast DNA repair protein RAD23 (hHR23A) requires its xeroderma pigmentosum complementation group C binding (XPCB) domain as well as the ubiquitin-associated 2 (UBA2) domain.
Jung J et al.
The Journal of Biological Chemistry, 2014
TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems.
Wynne C et al.
Plos One, 2014
Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1.
Gilder AS et al.
Biochemical and Biophysical Research Communications, 2013