Varaico: Literature-Extracted Genetic Variants

Gene:UBC
Variant:p.V26L
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UBC

NM_021009.7:p.V26L

Associated Papers

The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.

Wapenaar H et al.

Embo Reports, 2024

39528729 (PubMed )
Supplement: 44319_2024_306_MOESM11_ESM.pdf

BRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation.

Witus SR et al.

The Embo Journal, 2023

Using AlphaFold to predict the impact of single mutations on protein stability and function.

Pak MA et al.

Plos One, 2023

36928239 (PubMed )
Supplement: pone.0282689.s001.xlsx › Table_S1

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination.

Becker JR et al.

Nature, 2021

Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin.

Dai L et al.

Molecular Cell, 2021

Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.

Grau D et al.

Nature Communications, 2021

Structural basis for the multi-activity factor Rad5 in replication stress tolerance.

Shen M et al.

Nature Communications, 2021

33436623 (PubMed )
Supplement: 41467_2020_20538_MOESM1_ESM.pdf

KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface.

Yin G et al.

Iscience, 2020

32882514 (PubMed )
Supplement: mmc1.pdf

PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1.

Belotserkovskaya R et al.

Nature Communications, 2020

Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS.

Hsu PL et al.

Molecular Cell, 2019

Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination.

Liess AKL et al.

Structure (london, England : 1993), 2019

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome.

Sundaramoorthy R et al.

Elife, 2018

Core-directed protein design. II. Rescue of a multiply mutated and destabilized variant of ubiquitin.

Finucane MD et al.

Biochemistry, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."