Associated Papers
Functional landscape of ubiquitin linkages couples K29-linked ubiquitylation to epigenome integrity.
Arroyo-Gomez J et al.
The Embo Journal, 2025
Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.
Ahmed SF et al.
Molecular Therapy : the Journal of the American Society of Gene Therapy, 2025
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.
Li W et al.
The Embo Journal, 2025
Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase.
Carrillo Roas S et al.
Molecular Cell, 2025
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Hao X et al.
The Embo Journal, 2025
Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation.
Yoshida Y et al.
Molecular Cell, 2024
The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes.
Saha S et al.
Nature Communications, 2023
Multiple E3 ligases control tankyrase stability and function.
Perrard J et al.
Nature Communications, 2023
Hyperubiquitylation of DNA helicase RECQL4 by E3 ligase MITOL prevents mitochondrial entry and potentiates mitophagy.
Hussain M et al.
The Journal of Biological Chemistry, 2023
Orphan quality control shapes network dynamics and gene expression.
Mark KG et al.
Cell, 2023
HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway.
Zhang G et al.
British Journal of Cancer, 2022
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones.
Nakagawa T et al.
Cell Reports, 2022
MITOL-dependent ubiquitylation negatively regulates the entry of PolγA into mitochondria.
Hussain M et al.
Plos Biology, 2021
Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination.
Langerová H et al.
Cells, 2020
Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.
Nakazawa Y et al.
Cell, 2020
Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays.
Tan W et al.
Elife, 2020
The Human Cytomegalovirus pUL145 Isoforms Act as Viral DDB1-Cullin-Associated Factors to Instruct Host Protein Degradation to Impede Innate Immunity.
Le-Trilling VTK et al.
Cell Reports, 2020
Proteomics Links Ubiquitin Chain Topology Change to Transcription Factor Activation.
Li Y et al.
Molecular Cell, 2019
Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination.
Liess AKL et al.
Structure (london, England : 1993), 2019
BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor.
Priyadarshini R et al.
Cell Reports, 2018
Assembly and Function of Heterotypic Ubiquitin Chains in Cell-Cycle and Protein Quality Control.
Yau RG et al.
Cell, 2017
Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.
Tank EM et al.
Plos Genetics, 2009
Helix mutations stabilize a late productive intermediate on the folding pathway of ubiquitin.
Rea AM et al.
Biochemistry, 2008