Varaico: Literature-Extracted Genetic Variants

Gene:UBE2D2
Variant:p.C85S
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UBE2D2

NM_003339.3:p.C85S

Associated Papers

Linked-domain inhibitors designed to block UBE2D induce the unfolded protein response.

Bukhari Z et al.

Cell Chemical Biology, 2025

Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation.

Tey PY et al.

Biorxiv : the Preprint Server for Biology, 2024

Targeted protein degradation bypassing cereblon and von Hippel-Lindau.

Lu W

Innovation (cambridge (mass.)), 2023

MUL1-RING recruits the substrate, p53-TAD as a complex with UBE2D2-UB conjugate.

Lee MS et al.

The Febs Journal, 2022

Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice.

Humpton TJ et al.

Genes & Development, 2021

Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases.

Chatrin C et al.

Science Advances, 2020

Molecular Characterization of LubX: Functional Divergence of the U-Box Fold by Legionella pneumophila.

Quaile AT et al.

Structure (london, England : 1993), 2015

BIRC7-E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer.

Dou H et al.

Nature Structural & Molecular Biology, 2012

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.

Nakada S et al.

Nature, 2010

Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.

Kamadurai HB et al.

Molecular Cell, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."