Varaico: Literature-Extracted Genetic Variants

Gene:UBE2I
Variant:p.C93S
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UBE2I

NM_003345.5:p.C93S

Associated Papers

Mitochondrial SENP2 regulates the assembly of SDH complex under metabolic stress.

Liu Y et al.

Cell Reports, 2023

Sumoylation of the Carboxy-Terminal of Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Attenuates Viral DNA Replication.

Chen J et al.

Frontiers in Microbiology, 2021

Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification.

Heras G et al.

Journal of Molecular Cell Biology, 2019

UBC9 regulates cardiac sodium channel Nav1.5 ubiquitination, degradation and sodium current density.

Tang B et al.

Journal of Molecular and Cellular Cardiology, 2019

The SLX4 complex is a SUMO E3 ligase that impacts on replication stress outcome and genome stability.

Guervilly JH et al.

Molecular Cell, 2015

The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases.

Hsieh FS et al.

Biochimica Et Biophysica Acta, 2014

TAB2, an important upstream adaptor of interleukin-1 signaling pathway, is subject to SUMOylation.

Wang X et al.

Molecular and Cellular Biochemistry, 2014

UBC9 regulates the stability of XBP1, a key transcription factor controlling the ER stress response.

Uemura A et al.

Cell Structure and Function, 2013

Ubc9 mediates nuclear localization and growth suppression of BRCA1 and BRCA1a proteins.

Qin Y et al.

Journal of Cellular Physiology, 2011

Identification of a molecular recognition feature in the E1A oncoprotein that binds the SUMO conjugase UBC9 and likely interferes with polySUMOylation.

Yousef AF et al.

Oncogene, 2010

SUMOylation modulates the function of Aurora-B kinase.

Fernández-Miranda G et al.

Journal of Cell Science, 2010

Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene.

Kuo FT et al.

Cellular Signalling, 2009

A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells.

Xu J et al.

International Journal of Oncology, 2009

Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif.

Tremblay AM et al.

Molecular Endocrinology (baltimore, Md.), 2008

SUMOylation modulates transcriptional repression by TRPS1.

Kaiser FJ et al.

Biological Chemistry, 2007

Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.

Yunus AA et al.

Nature Structural & Molecular Biology, 2006

Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9.

Chakrabarti SR et al.

Proceedings of the National Academy of Sciences of the United States of America, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."