Associated Papers
The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells.
Chang Y et al.
Developmental Cell, 2024
Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition.
Li Y et al.
Cell Reports, 2024
Adenovirus oncoprotein E4orf6 triggers Cullin5 neddylation to activate the CLR5 E3 ligase for p53 degradation.
Guo H et al.
Biochemical and Biophysical Research Communications, 2019
NEDDylation promotes stress granule assembly.
Jayabalan AK et al.
Nature Communications, 2016
Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.
Cukras S et al.
Plos One, 2014
Destabilization of CDC6 upon DNA damage is dependent on neddylation but independent of Cullin E3 ligases.
Tan CY et al.
The International Journal of Biochemistry & Cell Biology, 2013
Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity.
Ponyeam W et al.
Cellular Signalling, 2012
Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis.
Laifenfeld D et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2007
Substrate-mediated regulation of cullin neddylation.
Chew EH et al.
The Journal of Biological Chemistry, 2007
Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells--evidence for cullin dimerization.
Chew EH et al.
Cellular Signalling, 2007
ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis.
Chen Y et al.
Journal of Neurochemistry, 2003
The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons.
Chen Y et al.
The Journal of Biological Chemistry, 2000
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