Varaico: Literature-Extracted Genetic Variants

Gene:UBE2S
Variant:p.C95S
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UBE2S

NM_014501.3:p.C95S

Associated Papers

Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S.

Liess AKL et al.

Science Signaling, 2020

Ube2s stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development.

Li Z et al.

Cell Death & Disease, 2018

UBE2S, a novel substrate of Akt1, associates with Ku70 and regulates DNA repair and glioblastoma multiforme resistance to chemotherapy.

Hu L et al.

Oncogene, 2017

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.

Bremm A et al.

Nature Structural & Molecular Biology, 2010

UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.

Garnett MJ et al.

Nature Cell Biology, 2009

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."