Associated Papers
Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury.
Mi Z et al.
Ageing Research Reviews, 2023
Structural basis for specific inhibition of the deubiquitinase UCHL1.
Grethe C et al.
Nature Communications, 2022
Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA.
Sheedlo MJ et al.
Biochemistry, 2021
Corrigendum: Ubiquitin C-Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine-Based Inhibitor.
Krabill AD et al.
Chembiochem : a European Journal of Chemical Biology, 2020
The evolutionarily conserved deubiquitinase UBH1/UCH-L1 augments DAF7/TGF-β signaling, inhibits dauer larva formation, and enhances lung tumorigenesis.
Nagata A et al.
The Journal of Biological Chemistry, 2020
A cysteine near the C-terminus of UCH-L1 is dispensable for catalytic activity but is required to promote AKT phosphorylation, eIF4F assembly, and malignant B-cell survival.
Hussain S et al.
Cell Death Discovery, 2019
S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation.
Kumar R et al.
Scientific Reports, 2017
Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor.
Hussain S et al.
Molecular and Cellular Biology, 2013
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7.
Zhang Y et al.
Nature Chemical Biology, 2013
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