Varaico: Literature-Extracted Genetic Variants

Gene:UGDH
Variant:p.G456A
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UGDH

NM_003359.4:p.G456A

Associated Papers

Structural Evolution of Primate Glutamate Dehydrogenase 2 as Revealed by In Silico Predictions and Experimentally Determined Structures.

Litso I et al.

Biomolecules, 2023

Transgenic expression of the positive selected human GLUD2 gene improves in vivo glucose homeostasis by regulating basic insulin secretion.

Petraki Z et al.

Metabolism: Clinical and Experimental, 2019

The odyssey of a young gene: structure-function studies in human glutamate dehydrogenases reveal evolutionary-acquired complex allosteric regulation mechanisms.

Zaganas IV et al.

Neurochemical Research, 2014

The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.

Spanaki C et al.

Neurochemistry International, 2012

Expression of human GLUD2 glutamate dehydrogenase in human tissues: functional implications.

Zaganas I et al.

Neurochemistry International, 2012

Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state.

Borompokas N et al.

The Journal of Biological Chemistry, 2010

Mutations in human GLUD2 glutamate dehydrogenase affecting basal activity and regulation.

Kanavouras K et al.

Journal of Neurochemistry, 2009

Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.

Kanavouras K et al.

Journal of Neuroscience Research, 2007

Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.

Kanavouras K et al.

Journal of Neuroscience Research, 2007

Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.

Zaganas I et al.

The Journal of Biological Chemistry, 2002

Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.

Mastorodemos V et al.

Journal of Neuroscience Research, 0

The human GLUD2 glutamate dehydrogenase: localization and functional aspects.

Zaganas I et al.

Neurochemistry International, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."