Varaico: Literature-Extracted Genetic Variants

Gene:UGDH
Variant:p.R443S
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UGDH

NM_003359.4:p.R443S

Associated Papers

Structural Evolution of Primate Glutamate Dehydrogenase 2 as Revealed by In Silico Predictions and Experimentally Determined Structures.

Litso I et al.

Biomolecules, 2023

Transgenic expression of the positive selected human GLUD2 gene improves in vivo glucose homeostasis by regulating basic insulin secretion.

Petraki Z et al.

Metabolism: Clinical and Experimental, 2019

Evolution of GLUD2 Glutamate Dehydrogenase Allows Expression in Human Cortical Neurons.

Spanaki C et al.

Molecular Neurobiology, 2016

Side-chain interactions in the regulatory domain of human glutamate dehydrogenase determine basal activity and regulation.

Mastorodemos V et al.

Journal of Neurochemistry, 2015

The odyssey of a young gene: structure-function studies in human glutamate dehydrogenases reveal evolutionary-acquired complex allosteric regulation mechanisms.

Zaganas IV et al.

Neurochemical Research, 2014

The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.

Spanaki C et al.

Neurochemistry International, 2012

Expression of human GLUD2 glutamate dehydrogenase in human tissues: functional implications.

Zaganas I et al.

Neurochemistry International, 2012

The human GLUD2 glutamate dehydrogenase and its regulation in health and disease.

Plaitakis A et al.

Neurochemistry International, 2011

Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state.

Borompokas N et al.

The Journal of Biological Chemistry, 2010

Mutations in human GLUD2 glutamate dehydrogenase affecting basal activity and regulation.

Kanavouras K et al.

Journal of Neurochemistry, 2009

Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.

Kanavouras K et al.

Journal of Neuroscience Research, 2007

Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.

Kanavouras K et al.

Journal of Neuroscience Research, 2007

Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine.

Zaganas I et al.

The Journal of Biological Chemistry, 2002

Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.

Mastorodemos V et al.

Journal of Neuroscience Research, 0

The human GLUD2 glutamate dehydrogenase: localization and functional aspects.

Zaganas I et al.

Neurochemistry International, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."