Varaico: Literature-Extracted Genetic Variants

Gene:UGT1A1
Variant:p.L131M
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UGT1A1

NM_000463.3:p.L131M

Associated Papers

The UGT1A9*22 genotype identifies a high-risk group for irinotecan toxicity among gastric cancer patients.

Lee CK et al.

Genomics & Informatics, 2022

36239106 (PubMed )
Supplement: gi-22051suppl1.pdf

Predicting drug response and toxicity in metastatic colorectal cancer: the role of germline markers.

Bignucolo A et al.

Expert Review of Clinical Pharmacology, 2022

Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review.

Stingl JC et al.

Pharmacology & Therapeutics, 2014

Differences in frequencies of UGT1A9, 1A7, and 1A1 genetic polymorphisms in Chinese Tibetan versus Han Chinese populations.

Yan W et al.

Genetics and Molecular Research : Gmr, 2013

Genetic variants and haplotypes of the UGT1A9, 1A7 and 1A1 genes in Chinese Han.

Zhang X et al.

Genetics and Molecular Biology, 2012

Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs.

Sai K et al.

Expert Opinion on Drug Metabolism & Toxicology, 2011

Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy.

Ramírez J et al.

Future Oncology (london, England), 2010

UGT1A1*28 and other UGT1A polymorphisms as determinants of irinotecan toxicity.

Biason P et al.

Journal of Chemotherapy (florence, Italy), 2008

Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.

Yea SS et al.

Therapeutic Drug Monitoring, 2008

Variability and function of family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A).

Strassburg CP et al.

Critical Reviews in Clinical Laboratory Sciences, 2008

Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer.

Nagar S et al.

Oncogene, 2006

Pharmacogenetics of uridine diphosphoglucuronosyltransferase (UGT) 1A family members and its role in patient response to irinotecan.

Nagar S et al.

Drug Metabolism Reviews, 2006

Predicting drug response and toxicity based on gene polymorphisms.

Robert J et al.

Critical Reviews in Oncology/hematology, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."