Varaico: Literature-Extracted Genetic Variants

Gene:UGT1A4
Variant:p.T36I
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UGT1A4

NM_007120.3:p.T36I

Associated Papers

No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants *2(P24T) or *3(L48V) in Norwegian patients.

Shirzadi M et al.

Seizure, 2017

Frequencies of UGT1A4*2 (P24T) and *3 (L48V) and their effects on serum concentrations of lamotrigine.

Reimers A et al.

European Journal of Drug Metabolism and Pharmacokinetics, 2016

Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10.

Kerdpin O et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2009

Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4.

Kubota T et al.

Molecular Pharmacology, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."