Varaico: Literature-Extracted Genetic Variants

Gene:UGT1A7
Variant:p.R131R
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UGT1A7

NM_019077.3:p.R131R

Associated Papers

Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by BRCA1 mutation.

Liu J et al.

Science Advances, 2025

40712032 (PubMed )
Supplement: sciadv.adi2370_tables_s8_and_s9.zip › adi2370_table_s9.xlsx › BRCA1-mutant_corrected_iPSC

Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease.

Cafiero C et al.

Pharmacogenomics and Personalized Medicine, 2020

Population pharmacogenetic pharmacokinetic modeling for flip-flop phenomenon of enteric-coated mycophenolate sodium in kidney transplant recipients.

Han N et al.

European Journal of Clinical Pharmacology, 2014

Differences in frequencies of UGT1A9, 1A7, and 1A1 genetic polymorphisms in Chinese Tibetan versus Han Chinese populations.

Yan W et al.

Genetics and Molecular Research : Gmr, 2013

S-1 plus irinotecan and oxaliplatin for the first-line treatment of patients with metastatic colorectal cancer: a prospective phase II study and pharmacogenetic analysis.

Kim SY et al.

British Journal of Cancer, 2013

Pharmacogenetic study of deferasirox, an iron chelating agent.

Lee JW et al.

Plos One, 2013

Genetic variants and haplotypes of the UGT1A9, 1A7 and 1A1 genes in Chinese Han.

Zhang X et al.

Genetics and Molecular Biology, 2012

Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer.

Wong NS et al.

Pharmacogenetics and Genomics, 2011

Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs.

Sai K et al.

Expert Opinion on Drug Metabolism & Toxicology, 2011

Part 3: Pharmacogenetic variability in phase II anticancer drug metabolism.

Deenen MJ et al.

The Oncologist, 2011

Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment.

Ginsberg G et al.

Critical Reviews in Toxicology, 2010

[Pharmacogenomics for adverse drug reactions].

Saito Y et al.

Nihon Rinsho. Japanese Journal of Clinical Medicine, 2010

Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy.

Ramírez J et al.

Future Oncology (london, England), 2010

Close association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 haplotype and its apparent influence on 7-ethyl-10-hydroxycamptothecin (SN-38) glucuronidation in Japanese.

Saito Y et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2009

Pharmacogenetic pathway analysis of irinotecan.

Rosner GL et al.

Clinical Pharmacology and Therapeutics, 2008

Update on tools for evaluation of uridine diphosphoglucuronosyltransferase polymorphisms.

Argikar UA et al.

Expert Opinion on Drug Metabolism & Toxicology, 2008

UGT1A1*28 and other UGT1A polymorphisms as determinants of irinotecan toxicity.

Biason P et al.

Journal of Chemotherapy (florence, Italy), 2008

Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population.

Yea SS et al.

Therapeutic Drug Monitoring, 2008

Combined UGT1A1 and UGT1A7 variant alleles are associated with increased risk of Gilbert's syndrome in Taiwanese adults.

Teng HC et al.

Clinical Genetics, 2007

Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28.

Minami H et al.

Pharmacogenetics and Genomics, 2007

Linkage disequilibrium of UGT1A1 *6 and UGT1A1 *28 in relation to UGT1A6 and UGT1A7 polymorphisms.

Urawa N et al.

Oncology Reports, 2006

Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene.

Machida H et al.

World Journal of Gastroenterology, 2005

UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan.

Carlini LE et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2005

Genetic polymorphisms of the UDP-glucuronosyltransferase 1A7 gene and irinotecan toxicity in Japanese cancer patients.

Ando M et al.

Japanese Journal of Cancer Research : Gann, 2002

Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis.

Ando Y et al.

Cancer Research, 2000

Fire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern Humans.

Aarts JM et al.

Plos One, 0

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